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A modified method for no carrier added radioiodination of L-tyrosine via chloramine-T as an oxidizing agent

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Abstract

A modified method for the preparation of L-[131/123I] iodotyrosine as a brain imaging agent is described. The method is based on direct electrophilic radioiodination of L-tyrosine with NaI [131/123I] using chloramine-T (CAT) and 0.001 μg KI as a carrier at pH 7.0. The product was purified by reverse phase high performance liquid chromatography (HPLC). A high radiochemical yield up to 85% of L-[131/123I] iodotyrosine has been achieved with radiochemical purity of greater than 97%. The relation between the pKa of L-tyrosine and pH of the reaction medium was calculated in order to correlate the radiochemical yield of L-[131/123I] iodotyrosine and the state of the three ionizable groups of L-tyrosine. Also, the influence of the reaction conditions on the radiochemical yield of L-[131/123I] iodotyrosine was investigated.

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Authors and Affiliations

  1. Labelled Compounds Department, Isotope Production Division, Hot Labs Center, Atomic Energy Authority, P. O. 13759, Cairo, Egypt

    A. A. El-Mohty, A. S. El-Wetery, M. T. El-Kolaly & M. Raieh

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  1. A. A. El-Mohty
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  2. A. S. El-Wetery
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  3. M. T. El-Kolaly
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  4. M. Raieh
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El-Mohty, A.A., El-Wetery, A.S., El-Kolaly, M.T. et al. A modified method for no carrier added radioiodination of L-tyrosine via chloramine-T as an oxidizing agent. Journal of Radioanalytical and Nuclear Chemistry Letters 214, 133–146 (1996). https://doi.org/10.1007/BF02164813

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  • DOI: https://doi.org/10.1007/BF02164813

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