Sur l'interaction entre aldéhydes ou réductones et acides aminés ou protéines

Summary

Proteins were exposed to acetaldehyde vapour or mixed with glucose in solution and the basic groups determined by their dy binding capacity. Only serum albumin shows a marked decrease of basic groups and of the carbon/nitrogen ratio as a sign of condensation of aldehyde and amine groups. These results were corroborated by the direct estimation of the aldehyde resine formed on the protein: serum albumin and fibrin treated with acetaldehyde vapour contained 5 to 10 times more resin than the other proteins examined. No rapid combination between serum proteins and glucose could be demonstrated by the dy method or by the kinetics of change of pH. The slow reaction seems not to be dependent on denaturation.