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Über die Bedeutung der Nierentätigkeit für die Blutdruckwirkungen eines dehydrierten Ergotderivats, Dihydroergocornin

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Summary

The present report analyses the blood-pressure action of dihydroergocornine (DHO) in anæsthetized animals without artificial hypertension. Experiments are carried out on intact and nephrectomized animals in cats in which the renal arteries are temporarily clamped, in cats with section of the thoracic spinal cord, and in dogs with grafted kidney. Evidence is presented that the changes in blood-pressure following dihydroergocornine in the intact animal are the result of at least two interacting mechanisms. The one (leading to a depressor effect) is only apparent if certain nervous mechanisms are intact, while the second (leading to a pressor effect) depends on renal function. It is probable that these effects on the circulatory system are produced by different active principles. Experiments in dogs with grafted kidney show that the secondary blood-pressure effect following dihydroergocornine is caused predominantly, to say the least, by means of a humoral mechanism of renal origin.

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References

  1. H. J. Bluntschli undR. H. Goetz, Amer. Heart J.35, 873 (1948).

    Article  CAS  Google Scholar 

  2. H. J. Bluntschli, Proc. of the 34th S. Afr. Med. Congress, (Knox Co., Durban, 1946), and S. Afr. Med. J.21, 21 (1947).

    CAS  Google Scholar 

  3. H. J. Bluntschli undR. H. Goetz, Schweiz. med. Wschr.77, 769 (1947); S. Afr. Med. J.21, 382 (1947).

    CAS  Google Scholar 

  4. E. D. Freis, J. R. Stanton undR. W. Wilkins, Amer. J. Méd. Sci.216, 163 (1948).

    Article  CAS  Google Scholar 

  5. H. J. Bluntschli, Helv. med. acta,15, 417 (1948).

    CAS  Google Scholar 

  6. Versuche an 48 Katzen (Urethannarkose) und an 14 Hunden (Morphinurethannarkose).

  7. Versuchsanordnung in Anlehnung an die Methode vonJ. C. Fasciolo, B. A. Houssay undA. C. Taquini, J. Physiol.94, 281 (1938).

    Article  CAS  Google Scholar 

  8. E. Rothlin, Schweiz. med. Wschr.77, 1161 (1947).

    CAS  Google Scholar 

  9. H. J. Bluntschli, Helv. physiol. acta6, C 50, (1948).

    Google Scholar 

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Authors and Affiliations

  1. Medizinische Universitätsklinik, Bürgerspital Basel, Switzerland

    H. J. Bluntschli & H. Staub

Authors
  1. H. J. Bluntschli
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  2. H. Staub
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Additional information

Über Chemie und Pharmakologie von Dihydroergocornin siehe: 1a A. Stoll undA. Hofmann, Helv. chim. acta26, 2070 (1943). 1b E. Rothlin, Helv. physiol. acta2, C 48 (1944). 1c E. Rothlin, Bull. acad. Suisse Sci. méd.2, 249 (1947).

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Bluntschli, H.J., Staub, H. Über die Bedeutung der Nierentätigkeit für die Blutdruckwirkungen eines dehydrierten Ergotderivats, Dihydroergocornin. Experientia 5, 46–48 (1949). https://doi.org/10.1007/BF02164655

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