Summary
G. Mansfeld demonstrated that in the serum of overheated animals a substance (thermothyrine A) is present which, injected into normal animals, decreases O2-consumption. Serum of thyroidectomized animals has no effect.
Dogs and rabbits were treated daily with 0.10 g per kg methylthiouracil during 4 weeks, and were than subjected for 5 hours to a temperature of 34–35° C which raised their body temperature by 0.5–1.5° C. 2.5 cm3 of serum obtained at the end of the 5 hours period failed to reduce O2-consumption of normal rats, while sera of untreated dogs and rabbits produced after similar exposure to high temperature a fall of O2-consumption by 14–48%. It is therefore evident that methylthiouracil not only inhibits the formation of thyroxine but of thermothyrine A as well.
The fact that thermothyrine A contains no iodine proves conclusively that the action of thiouracil compounds cannot be exclusively an inhibition of iodinization.
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von Berde, B. Aufhebung der Thermothyrin-A-Sekretion der Schilddrüse durch Fütterung mit Methylthiouracil. Experientia 3, 245–247 (1947). https://doi.org/10.1007/BF02164146
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DOI: https://doi.org/10.1007/BF02164146