Experientia

, Volume 3, Issue 5, pp 176–184 | Cite as

Die Biochemie der Chinone

  • Otto Hoffmann-Ostenhof
Article

Summary

The first part of this survey gives a short but complete description of all quinones hitherto found as natural products. The substances with vitamin-K-activity and the echinochromes are treated in special chapters. In the second part the author deals with some biochemical and pharmacological effects due to quinone derivatives. The reactions with proteins and the inhibition effects on certain enzymes are discussed. Special stress is laid on the carcinogenous effects and the antibiotic activity of some quinones. The author tries to give an explanation of the acting mechanism of the latter based partly on his own recent experiments. The survey is concluded with a chapter on the toxicology of the quinones. Though quinones—save the substances with vitamin-K-activity—until now were not used very much in therapeutics, there is hope that with further investigation on this subject some of the mentioned substances will prove of clinical value.

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Literatur

  1. 1.
    Vgl. zu diesem AbsatzO. Gerngross im Handbuch der Gerbereichemie (Herausgeber W. Graßmann), Wien 1939, II/2, und zwar S. 384ff.Google Scholar
  2. 1.
    E. Fischer undH. Schrader, Ber. dtsch. chem. Ges.43, 525 (1910).Google Scholar
  3. 2.
    S. Hilpert undF. Brauns, Collegium 64 (1925).Google Scholar
  4. 1.
    A. W. Thomas undS. B. Foster, J. Amer. chem. Soc.48, 489 (1926).CrossRefGoogle Scholar
  5. 2.
    R. Kuhn undH. Beinert, Ber. dtsch. chem. Ges.77, 606 (1944).Google Scholar
  6. 1.
    J. H. Quastel, Bioch. J.27, 1116 (1933).Google Scholar
  7. 2.
    H. Fischgold, Bioch. J.28, 10 (1934).Google Scholar
  8. 3.
    O. Hoffmann-Ostenhof undW. H. Lee, Mh. Chem.76, 180 (1946).Google Scholar
  9. 4.
    R. M. Pearson undJ. A. B. Smith, Bioch. J.37, 142, 148, 153 (1943).Google Scholar
  10. 1.
    T. Bersin undW. Logemann, Hoppe-Seylers Z. physiol. Chem.220, 209 (1933).Google Scholar
  11. 2.
    L. Hellerman undM. E. Perkins, J. biol. Chem.107, 241 (1934).Google Scholar
  12. 3.
    O. Hoffmann-Ostenhof undE. Biach, Exper.2, 405 (1946); Mh. Chem. (im Druck).CrossRefGoogle Scholar
  13. 1.
    H. Wieland undK. Frage, Liebigs Ann. Chem.477, 1 (1929).Google Scholar
  14. 1a.
    H. Wieland undA. Lawson,ib. Exper.485, 193 (1931).Google Scholar
  15. 2.
    H. Wieland undW. Mitchell,ib. Exper.492, 156 (1932).Google Scholar
  16. 3.
    H. Wieland undH. J. Pistor,ib. Exper.535, 205 (1938).Google Scholar
  17. 4.
    H. Wieland undO. B. Claren,ib. Exper.509, 182 (1934).Google Scholar
  18. 5.
    A. Alexejew undK. Russinowa, Bull. Inst. Rech. biol. Perm.6, 425 (1928).Google Scholar
  19. 6.
    O. Hoffmann-Ostenhof undE. Biach, Mh. Chem.76, 319 (1947).Google Scholar
  20. 7.
    O. Hoffmann-Ostenhof, Exper.3, 152 (1947).CrossRefGoogle Scholar
  21. 8.
    R. Kuhn undH. Beinert, Ber. dtsch. chem. Ges.76, 904 (1943).Google Scholar
  22. 9.
    K. Wallenfels, Chemie57, 1 (1945).Google Scholar
  23. 1.
    H. Süllmann, Helv. chim. acta26, 2253 (1943).CrossRefGoogle Scholar
  24. 2.
    R. Meier undM. Allgöwer, Exper.1, 57 (1945).CrossRefGoogle Scholar
  25. 3.
    F. E. Lehmann, Rev. suisse Zool.52, 342 (1945).Google Scholar
  26. 4.
    W. Huber,ib. Rev. suisse Zool.52, 354 (1945).Google Scholar
  27. 5.
    E. A. Cooper, Bioch. J.7, 186 (1913).Google Scholar
  28. 6.
    G. T. Morgan undE. A. Cooper,ib. Bioch. J.15, 587 (1921); J. Soc. chem. Ind.43, T. 352 (1924).Google Scholar
  29. 1.
    E. A. Cooper undS. D. Nicholas, J. Soc. chem. Ind.46, T. 59 (1927).Google Scholar
  30. 1a.
    E. A. Cooper undR. B. Haines, Bioch. J.23, 4 (1930).Google Scholar
  31. 2.
    A. E. Oxford undH. Raistrick, Chem. Industry61, 128 (1942).Google Scholar
  32. 2a.
    H. Raistrick undG. Smith,ib. Chem. Industry60, 828 (1941).Google Scholar
  33. 2b.
    A. E. Oxford,ib. Chem. Industry61, 49 (1942).Google Scholar
  34. 3.
    A. E. Oxford,ib. Chem. Industry61, 189 (1942).Google Scholar
  35. 1.
    Zit. beiK. Wallenfels, Chemie57, 1 (1945).Google Scholar
  36. 2.
    A. E. Oxford, Bioch. J.36, 438 (1942).Google Scholar
  37. 1.
    H. R. V. Arnstein, A. H. Cook undM. S. Lacey, Nature157, 333 (1946).Google Scholar
  38. 1.
    K. Wallenfels, Chemie57, 1 (1945).Google Scholar
  39. 2.
    C. J. Cavalito, J. biol. Chem.164, 29 (1946).Google Scholar
  40. 2a.
    C. A. Collwell undM. McCall, J. Bacteriol.51, 659 (1946).Google Scholar
  41. 1.
    L. v. Bertalanffy, O. Hoffmann-Ostenhof undO. Schreier, Nature158, 948 (1946).Google Scholar
  42. 1a.
    O. Hoffmann-Ostenhof undG. Reitmaier, Mh. Chem. (im Druck).Google Scholar
  43. 2a.
    R. Meier undM. Allgöwer, Exper.1, 57 (1945).CrossRefGoogle Scholar
  44. 1.
    H. J. Almquist, L. F. Pentler undF. Mecchi, Proc. Soc. exp. Biol. Med.38, 336 (1938).Google Scholar
  45. 2.
    D. W. Woolley undJ. R. McCarter,ib. Proc. Soc. exp. Biol. Med.45, 357 (1940).Google Scholar
  46. 2a.
    Vgl. auchB. C. J. G. Knight, Vitamins and Hormones3, 105 (1945).Google Scholar
  47. 3.
    N. Takizawa, Proc. Imp. Acad. (Tokyo),16, 309 (1940).Google Scholar
  48. 4.
    R. Kuhn undH. Beinert, Ber. dtsch. chem. Ges.76, 904 (1943).Google Scholar
  49. 5.
    C. J. Kensler, S. O. Dexter undC. P. Rhoads, Cancer. Res.2, 1 (1942).Google Scholar
  50. 5a.
    C. J. Kensler, N. F. Young undC. P. Rhoads, J. biol. Chem.143, 465 (1942).Google Scholar
  51. 1.
    A. Oparin, Bioch. Z.182, 155 (1927).Google Scholar
  52. 2.
    W. Palladin, Ber. dtsch. bot. Ges.30, 104 (1912).Google Scholar
  53. 3.
    I. Banga undE. Phillippot, Hoppe-Seylers Z. physiol. Chem.258, 147 (1939).Google Scholar
  54. 3a.
    Vgl. auchA. v. Szent-Györgyi undK. Vietorisz, Bioch. Z.233, 236 (1931).Google Scholar
  55. 1.
    O. Warburg undW. Lüttgens, Naturwiss.32, 161 und 301 (1944).CrossRefGoogle Scholar
  56. 2.
    V. B. Wigglesworth, Exper.2, 210 (1946).Google Scholar
  57. 3.
    O. Schulz, Inaug.-Diss., Rostock 1892.Google Scholar
  58. 4.
    S. Cohn, Inaug.-Diss., Königsberg 1893.Google Scholar
  59. 5.
    Vgl. dazu das Sammelreferat vonW. Heubner, Erg. Physiol.43, 9 (1940).Google Scholar
  60. 1.
    O. Hoffmann-Ostenhof, W. Weis undO. Kraupp, Mh. Chem. (im Druck).Google Scholar
  61. 2.
    S. Baglioni, Z. allg. Physiol.3, 313 (1900).Google Scholar
  62. 1.
    Vgl. z.B. M. B. Shimkin, J. Pharmacol. exper. Therap.71, 210 (1941).Google Scholar

Copyright information

© Birkhäuser Verlag 1947

Authors and Affiliations

  • Otto Hoffmann-Ostenhof
    • 1
  1. 1.Wien

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