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Preparation of [48V]-VO2+ for biomedical studies

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Abstract

A new method for the highly efficient separation of48V for radiotracer experiments is presented. It is based on the proton irradiation of a high purity Ti plate which is dissolved in sulfuric acid to form Ti3+ and V4+. Both ions are quantitatively absorbed on AG50W-X8 cation exchange resin and are converted to the respective higher valence state by an on-column reaction with diluted nitric acid and hydrogen peroxide. The eluate containing V5+ is evaporated to dryness in presence of sulfuric acid and treated with ethanol to reduce [48V]-vanadate to [48V]-vanadyl for labeling experiments in pharmaceutical research.

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Authors and Affiliations

  1. TRIUMF, 4004 Wesbrook Mall, V6R 2Z9, Vancouver, BC, Canada

    S. K. Zeisler & T. J. Ruth

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  1. S. K. Zeisler
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  2. T. J. Ruth
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Zeisler, S.K., Ruth, T.J. Preparation of [48V]-VO2+ for biomedical studies. Journal of Radioanalytical and Nuclear Chemistry Letters 200, 283–290 (1995). https://doi.org/10.1007/BF02163782

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  • DOI: https://doi.org/10.1007/BF02163782

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