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Effect of cuprous ion on labeling of three skeletal imaging agents with99mTc

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Abstract

The effect of increased content of copper on the radiochemical composition of three skeletal imaging agents:99mTc(Sn)-methylene diphosphonate (MDP),99mTc(Sn)-pyrophosphate (PYP) and99mTc(Sn)-2,3-dicarboxypropane-1, 1-diphosphonate (DPD) was observed only in the case of99mTc(Sn)-MDP. It was found that the radiochemical purity of this radiopharmaceutical falls to about 50% when the copper content reaches about 10−5 mol dm−3. According to the results of radiochemical and biological analyses, it could be concluded that with the increase of copper content, the content of free pertechnetate rises, too. The two other radiopharmaceuticals,99mTc(Sn)-PYP and99mTc(Sn)-DPD, were found to be stable under the given experimental conditions.

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Authors and Affiliations

  1. The Laboratory for Radioisotopes, The Institute of Nuclear Sciences “Vinča”, P. O. Box 522, 11001, Belgrade, Yugoslavia

    J. Vučina, D. Vuga, T. Maksin & N. Vanlić-Razumenić

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  1. J. Vučina
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  2. D. Vuga
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  3. T. Maksin
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  4. N. Vanlić-Razumenić
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Vučina, J., Vuga, D., Maksin, T. et al. Effect of cuprous ion on labeling of three skeletal imaging agents with99mTc. Journal of Radioanalytical and Nuclear Chemistry Letters 186, 333–339 (1994). https://doi.org/10.1007/BF02162617

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  • DOI: https://doi.org/10.1007/BF02162617

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