Summary
The influence of iproniazid and isoniazid on the 5-hydroxytryptamine (5HT) content of the brain and on the reserpine-induced decrease of 5HT in the brain was investigated in rats, mice and rabbits. The following results were obtained:
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(1)
The 5HT content showed a significant increase after one dose of 100 mg/kg iproniazid, whereas with the same dose of isoniazid no marked effect was observed.
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(2)
Preliminary treatment with iproniazid reduced the 5HT depression in the brain caused by reserpine. This effect persisted for four days after reserpine administration. Isoniazid did not influence the reserpine-induced decrease of 5HT in the brain.
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Literatur
A. Pletscher, P. A. Shore undB. B. Brodie, J. Pharmacol. exp. Ther.116, 46 (1956).
P. A. Shore, S. L. Silver undB. B. Brodie, Science122, 284 (1955).
E. A. Zeller, J. Barsky, J. R. Fouts, W. F. Kirchheimer undL. S. van Orden, Exper.8, 349 (1952).
E. A. Zeller, J. Barsky, E. R. Berman undJ. R. Fouts, J. lab. clin. Med.40, 965 (1952).
E. A. Zeller undJ. Barsky, Proc. Soc. exp. Biol. Med.81, 459 (1952).
R. W. Schayer, Proc. Soc. exp. Biol. Med.84, 60 (1953).
E. A. Zeller, J. Barsky undE. R. Berman, J. Biol. Chem.214, 267 (1955).
D. F. Bogdanski, H. Weissbach undS. Udenfriend, Fed. Proc.15, 402 (1956).
S. Udenfriend, D. F. Bogdanski undH. Weissbach, Fed. Proc.15, 493 (1956).
S. Udenfriend, H. Weissbach undD. F. Bogdanski, im Druck;idem, in Vorbereitung.
P. A. Shore, A. Pletscher, E. G. Tomich, A. Carlsson, R. Kuntzman undB. B. Brodie, Ann. N. Y. Acad. Sci., im Druck.
A. H. Sjoerdsma, H. Weissbach undS. Udenfriend, Amer. J. Med.22, 520 (1956).
H. Besendorf undA. Pletscher, Helv. physiol. Acta (1956) im Druck.
B. B. Brodie, A. Pletscher undP. A. Shore, J. Pharmacol. exp. Ther.116, 9 (1956).
M. Chessin, B. Dubnick, E. R. Kramer undC. C. Scott, Fed. Proc.15, 409 (1956).
E. A. Zeller undJ. Barsky, Proc. Soc. exp. Biol. Med.81, 459 (1952).
R. W. Schayer, Proc. Soc. exp. Biol. Med.84, 60 (1953).
H. Besendorf undA. Pletscher, Helv. physiol. Acta (1956). im Druck.
S. Udenfriend, H. Weissbach undD. F. Bogdanski, im Druck.
B. B. Brodie, A. Pletscher undP. A. Shore, J. Pharmacol. exp. Ther.116, 9 (1956).
D. F. Bogdanski, A. Pletscher, B. B. Brodie undS. Udenfriend, J. Pharmacol. exp. Ther.117, 82 (1956).
Erhältlich bei Farrand Optical Co., Inc., New York 70, N. Y.
R. L. Bowman, P. A. Caulfield undS. Udenfriend, Science122, 32 (1955).
B. B. Brodie undP. A. Shore, Ann. N. Y. Acad. Sci., im Druck.
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Pletscher, A. Beeinflussung des 5-Hydroxytryptaminstoffwechsels im Gehirn durch Isonikotinsäurehydrazide. Experientia 12, 479–480 (1956). https://doi.org/10.1007/BF02162532
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DOI: https://doi.org/10.1007/BF02162532