Skip to main content
SpringerLink
Log in

Radiobiokinetic evaluation of domestic cold kits

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Domestically produced diagnostic cold kits, viz. glucoheptonate (GH), diisopropyliminodiacetic acid (DISIDA), dimercaptosuccinic acid (DMSA), diethylenetriamine-pentaacetic acid (DTPA), methylenediphosphonate (MDP) and Sn-colloid were labeled with99mTc and their in-vivo distribution in experimental animals (rats) was evaluated prior to use in humans for diagnostic scanning. The biodistribution pattern was found in accordance with the latest guidelines of the International Atomic Energy Agency (IAEA), which serve as a standard for small scale producers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L.J. Roth (Ed.), Isotopes in Experimental Pharmacology, University of Chicago Press, Chicago, USA, 1965.

    Google Scholar 

  2. Y. Cohen (Ed.), Radionuclide Pharmacology; Section 78 of the International Encyclopedia of Pharmacology and Therapeutics, Pergamon, Oxford, UK, 1971.

    Google Scholar 

  3. H.N. Wagner (Ed.), Principles of Nuclear Medicine, W.B. Saunders Co., Philadelphia, PA, USA, 1968.

    Google Scholar 

  4. K. Yamamoto, P. Som, A.B. Brill et al.,J. Nucl. Med., 27 (1986) 1178.

    PubMed  Google Scholar 

  5. IAEA Technical Report, Preparation of kits for99mTc radiopharmaceuticals, IAEA-TECDOC-649 (1992)

  6. M.B. Imran, S.J. Khurshid, H.M.A. Karim,J. Radioanal. Nucl. Chem., Lett., 176 (1993) 211.

    Google Scholar 

  7. S.J. Khurshid, H.M.A. Karim, Biological Quality Control of Radiopharmaceuticals, PINSTECH/NCD-23 (1986).

  8. S.J. Khurshid, Bibi Shahnaz, H.M.A. Karim, Sterility Control of Radiopharmaceuticals by Radiometric Methods, NCD/P-101 (1988).

  9. S.J. Khurshid,Specialist, 9(4) (1993) 359.

    Google Scholar 

  10. G. Subramanian,99mTc-Labeled Radiodiagnostic Agents: A Complation of Current Procedures, Upstate Medical Centre, Syracuse, N.Y., 1989.

    Google Scholar 

  11. S.J. Khurshid, M.Z. Sadiq, M.B. Imran, A. Wagar, Biological Quality Control-Radiopharmacokinetic Study of99mTc-radiopharmaceutical Kits, NCD/P-115 (1993).

  12. M.B. Imran, S.J. Khurshid, K. Anwar,Comput. Methods and Prog. in Biomedicine, (in press).

  13. M. Akhtar, A. Mushtaq, I. Haider, A. Aziz, H.M.A. Karim,J. Radioanal. Nucl. Chem., Lett., 146 (1990) 415.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nuclear Chemistry Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan

    M. Zubair Sadiq & S. Javaid Khurshid

  2. Centre for Nuclear Studies, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan

    M. B. Imran

Authors
  1. M. Zubair Sadiq
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. B. Imran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Javaid Khurshid
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sadiq, M.Z., Imran, M.B. & Khurshid, S.J. Radiobiokinetic evaluation of domestic cold kits. Journal of Radioanalytical and Nuclear Chemistry Letters 199, 79–88 (1995). https://doi.org/10.1007/BF02162470

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02162470

Keywords

Search

Navigation