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Synthesis of195mPt radiolabeled cisdiammine (glycolato) platinum (II) of high radionuclidic purity

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Abstract

An experimental method is described for the synthesis of195mPt-radiolabeled cis-diammine (glycolato) platinum (II) (254-S). Ten mg of 95% enriched194Pt was irradiated for 75 h in the hydraulic conveyer of KUR at a thermal neutron flux of ca. 8.15×1013 n·cm−2·s−1, and the195mPt-radiolabeled 254-S was synthesized and purified using HPLC (column: Dichrosorb Diol, elution: 80% CH3CN). The chemical yield was approximately 45%, with chemical purity greater than 98.4%. The radionuclidic purity was nearly 100% and the specific activity, 7.2 MBq·mg−1 254-S.

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Authors and Affiliations

  1. Research Reactor Institute, Kyoto University, Kumatori-cho, 590, Osaka, Japan

    K. Kawai, Y. Tanaka, Y. Nakano & M. Akaboshi

  2. Robert Koch Institute, D-1000, Berlin 65, Germany

    W. Ehrlich

Authors
  1. K. Kawai
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  2. Y. Tanaka
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  3. Y. Nakano
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  4. W. Ehrlich
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  5. M. Akaboshi
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Kawai, K., Tanaka, Y., Nakano, Y. et al. Synthesis of195mPt radiolabeled cisdiammine (glycolato) platinum (II) of high radionuclidic purity. Journal of Radioanalytical and Nuclear Chemistry Letters 199, 207–215 (1995). https://doi.org/10.1007/BF02162369

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  • DOI: https://doi.org/10.1007/BF02162369

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