Abstract
α-Methyltyrosine was iodinated in position 3 of the aromatic ring by means of an electrophilic iodination method using chloramine-T in a phosphate buffer solution. In a mixture containing α-methyltyrosine, chloramine-T and a small amount of NaI as a carrier the reaction was complete within 15 min at room temperature. After purification by radio high pressure liquid chromatography /HPLC/ radiochemical yields of 77.6±3.2% were obtained. Radiochromatograms also revealed a small amount of an impurity, probably chlorinated 3-123I-α-methyltyrosine. After dissolving in isotonic phosphate buffer and sterile filtration the solution was ready for nuclear-medical applications.
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Knust, E.J., Dutschka, K. & Machulla, H.J. Radiopharmaceutical preparation of 3-123I-α-methyltyrosine for nuclearmedical applications. Journal of Radioanalytical and Nuclear Chemistry Letters 144, 107–113 (1990). https://doi.org/10.1007/BF02162193
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DOI: https://doi.org/10.1007/BF02162193