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Über die Beziehungen zwischen Insulin und Zink in den Langerhansschen Inseln des Pankreas

Mit besonderer Berücksichtigung der blutzuckergesteuerten Insulinsekretion

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Summary

A collection is made of the findings of morphological and physiological investigations on the behaviour of theLangerhans islands of the pancreas, with regard to their regulating function. Histo-chemical investigations on the zinc content of the islands are especially described. On the basis of the chemical and physico-chemical relationships between insulin and zinc, an influence of this metal on the formation of intra-cellular insulin depots is presumed. Under the appropriate conditions, insulin, which is slightly soluble at physiological pH, forms an insoluble complex with zinc alone or together with basic proteins. Since insulin and zinc disappear from the islands after an increase of glucose, it follows that the glucose must be the indirect cause of a change in the insulin-zinc combination in the hormone depot. The metabolic processes which are involved in the insulin output induced by the blood sugar are discussed.

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  1. H. Medizinische Universitätsklinik München, Germany

    H. Maske

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Maske, H. Über die Beziehungen zwischen Insulin und Zink in den Langerhansschen Inseln des Pankreas. Experientia 11, 122–128 (1955). https://doi.org/10.1007/BF02161704

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