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An hypothesis for oxidative phosphorylation

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Résumé

Présentation d'une hypothèse pour la phosphorylation oxidative qui comprend des substances vinyl carbonyl, suivie d'une esquisse d'un système cyclique utilisant des quinones, hydroxyquinones, hydroxy-hydroquinones et leurs dérivés phosphorilatés.

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Author information

Authors and Affiliations

  1. Institute for Enzyme Research, University of Wisconsin, Madison

    H. I. Hadler

Authors
  1. H. I. Hadler
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Additional information

This investigation was supported by the grant of a Special Fellowship, Division of Medical Sciences; and partially supported by grant C-2399 National Cancer Institute, National Institutes of Health; Department of Health Education and Welfare.

The abbreviations used are DPN diphosphopyridine nucleotide, DPNH reduced diphosphopyridine nucleotide, ATP Adenosine triphosphate, ADP Adenosine diphosphate, Pi orthophosphate, P/O ratio of atoms of phosphorous and oxygen coupled through oxidative phosphorylation, DNP 2,4-dinitrophenol, E enzyme.

Acknowledgement: Thanks are due Dr.H. A. Lardy for his enthusiastic support, Dr.W. W. Cleland for his interest, and Mr.L. R. Gignilliat III for his counsel.

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Hadler, H.I. An hypothesis for oxidative phosphorylation. Experientia 17, 268–269 (1961). https://doi.org/10.1007/BF02161435

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