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Über die Chemie der Brassica-Faktoren, ihre Wirkung auf die Funktion der Schilddrüse und ihr Übergehen in die Milch

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Summary

The chemistry, and also the importance of goitrogenic substances derived from vegetables or fodder plants is dealt with. The most important new results are the following:

  1. (1)

    The precursor of SCN-, glucobrassicin, was isolated from plants belonging to theBrassica family. Its structure was established. It is a thioglucoside containing an indole group. Its enzymatic decomposition at different pH's was investigated. In addition to esters ofisothiocyanic acid, esters of thiocyanic acid were also found to be formed from thioglucosides in some plants by ‘myrosinase’.

  2. (2)

    Enzymatic formation of vinylthio-oxazolidone was found to occur also in the green parts of crushedBrassica plants. This antithyroid substance was determined in cabbage, marrow kale, and numerous other fodder plants.

  3. (3)

    The transfer of both SCN- and vinylthio-oxazolidone to milk was determined in experiments with cows. The amount of both substances transferred to milk was so small that it cannot make milk goitrogenic. The goitrogenic properties of milk produced by different kinds of feeding was investigated in human and rat experiments. Milk with goitrogenic properties could not be produced with any kind of feeding. Different experiments were performed to find the cause of the contradictory results presented in the literature.

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Authors and Affiliations

  1. Biochemisches Forschungsinstitut, Helsinki

    A. I. Virtanen

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  1. A. I. Virtanen
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Additional information

Nach einem Vortrag auf der Tagung der Nobelpreisträger in Lindau 6. 7. 1960. Der Artikel ist durch neue Befunde ergänzt worden. Die experimentellen Arbeiten wurden im Rahmen eines Forschungsprojekts unter U.S. Public Law 480 durchgefürht.

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Virtanen, A.I. Über die Chemie der Brassica-Faktoren, ihre Wirkung auf die Funktion der Schilddrüse und ihr Übergehen in die Milch. Experientia 17, 241–251 (1961). https://doi.org/10.1007/BF02161421

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