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Zur Biosynthese der Dipicolinsäure

Ein Beitrag zur Biologie der Sporenbildung

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Zeitschrift für Hygiene und Infektionskrankheiten, medizinische Mikrobiologie, Immunologie und Virologie Aims and scope Submit manuscript

Zusammenfassung

In der vorliegenden Arbeit wurde versucht, einen Einblick in die Biosynthese der Dipicolinsäure bei der Versporung von Bac. megaterium zu gewinnen.

Es wurde nachgewiesen, daß bei B. megaterium ein enger Zusammenhang zwischen Dipicolinsäuresynthese und Versporung besteht. Wenn auch die Biosynthese der Dipicolinsäure auf mehreren Wegen erfolgen kann, so konnte an Hand der erhobenen Befunde gezeigt werden, daß die Biosynthese der Dipicolinsäure am raschesten, leichtesten und mit der besten Ausbeute von einer C2- und einer C5-Verbindung ausgehend vor sich geht, am wahrscheinlichsten unter Benützung von Glyoxylsäure und Glutaminsäure als Ausgangsmaterial.

Die seit längerem bekannte Wirkung des Mangans als für die Versporung notwendiges Spurenelement konnte auf eine bisher noch nicht näher bestimmbare Aktivierung von Fermenten des Citronensäurecyclus zurückgeführt werden. Bei Anwesenheit von Glykolsäure können die Bacillen jene nur in Gegenwart von Mangan zu Glyoxylsäure oxydieren.

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    H. Benger

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Benger, H. Zur Biosynthese der Dipicolinsäure. Zeitschr. f. Hygiene. 148, 318–344 (1962). https://doi.org/10.1007/BF02161327

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