Freisetzung von Kalium aus denerviertem und innerviertem Skelettmuskel durch Acetylcholin
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Both hind limbs of cats (one being normally innervated, the other 8–12 days after denervation) were perfused and the quantities of potassium liberated from the two limbs in response to intraarterial injections of varying amounts of acetylcholine were compared by collecting the venous outflow from both sides separately; considerably larger quantities of potassium were found to be liberated from the denervated than from the innervated muscle after equal doses of ACH; the threshold dose of ACH for eliciting a measurable liberation of potassium being much lower on the denervated side. The dose response relation between injected ACH and potassium-liberation is of a different nature for innervated and denervated muscle. The results obtained are compatible with expectations derived from the “short circuit theory” of the transmitter action on the neuromuscular endplate (Fatt andKatz). The reasons of the difference in the dose relations for the innervated and denervated muscle are discussed.
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