Über ein carcinostatisch wirksames Hydrochinonderivat

Summary

The reaction between benzoquinone and two or more mols ethylenimine yields a white insoluble compound which is the internal salt of 2,5-bis-ethylenimino-hydroquinone, an unusual formation not yet described in the literature. C-Methyl-ethylenimine forms a similar hydroquinone salt, whilst other cyclic or non cyclic amines, such as piperidine, pyrrolidine, trimethylenimine, dimethylamine and C,C-dimethyl-ethylenimine give 2,5-disubstituted benzoquinones. According to the findings ofLoustalot, Schär andMeier 2,5-Bisethylenimino-hydroquinone has proved to be of remarkable efficacy in seven kinds of transplantable tumors. It would seem, therefore, that this compound has, both chemically and biologically, interesting qualities.