m-THPC photodynamic therapy for head and neck cancer
- 60 Downloads
Over the past 30 months, the authors have treated a wide variety of head and neck cancer patients with meta-tetrahydroxyphenylchlorin (mTHPC)-mediated photodynamic therapy (PDT). This drug is a powerful, second-generation photosensitizer with significant advantages over earlier drugs. Treatment ranged from palliation and adjunctive to curative procedures. Results to date are very encouraging, with marked advantages over standard methods of treatment with respect to morbidity, both functional and aesthetic. Potential cure rates remain essentially unchanged, very much dependent on the stage of the tumour. These promising early results justify a multicentre study for treatment of early head and neck cancer using this drug and light combination. This is now underway.
Key wordsPhotodynamic therapy Head and neck cancer Chlorin
Unable to display preview. Download preview PDF.
- 3.Bonnet R, Berenbaum MC. Porphyrins as photosensitizers. In: Bock G, Harnett S. (eds)Photosensitizing Compounds: their Chemistry, Biology and Clinical Use. Chichester, Wiley, CIBA Foundation Symposium146:40–59, 1989Google Scholar
- 4.Gomer CJ, Rucker N, Murphree AL. Preferential cell photosensitivity following porphyrin photodynamic therapy.Canc Res 1988,40:4539–42Google Scholar
- 5.Weishaupt KR, Gomer CJ, Dougherty TJ. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumour.Canc Res 1976,36:2326–9Google Scholar
- 6.Henderson BW, Wadlow SM, Mang TS, Potter WR et al. Tumour destruction and kinetics of tumour cell death in two experimental mouse tumours following photodynamic therapy.Canc Res 1985,45:572–6Google Scholar
- 9.Dilkes MG, DeJode ML. Alternative light sources for PDT (Abstract).Lasers Med Sci 1996, in pressGoogle Scholar
- 11.Dilkes MG. The Role of Adjunctive Intra-operative Photodynamic Therapy in Reducing Local Recurrence After Radical Neck Dissection—Safety and Efficacy Studies. MS Thesis, London University, UK, 1996.Google Scholar
- 15.Feyh J, Goetz A, Muller W et al. Photodynamic therapy in head and neck cancer.J Photochem Photobiol 1990,7:353–8Google Scholar
- 16.Gluckman JL. Photodynamic therapy for head and neck neoplasms.Otolaryngol Clin N Am 1991,24:1559–67Google Scholar
- 17.Monnier Ph, Savary M, Fontolliet Ch et al. Photodetection and photodynamic therapy of early SCC of the pharynx, oesophagus and tracheobronchial tree.Lasers Med Sci 1990,5:149–69Google Scholar
- 19.Schweizer VG, Bologna S, Batra SK. Photodynamic therapy for treatment of esophageal cancer: a preliminary report.Laryngoscope 1993,103:669–703Google Scholar
- 22.Dilkes MG, DeJode ML. meta-Tetrahydroxyphenylchlorin mediated photodynamic therapy. Experience and thoughts after 17 treatments.Proc S.P.I.E. 1995,2371:256–61Google Scholar