Lasers in Medical Science

, Volume 11, Issue 1, pp 23–29 | Cite as

m-THPC photodynamic therapy for head and neck cancer

  • M. G. Dilkes
  • M. L. DeJode
  • A. Rowntree-Taylor
  • J. A. McGilligan
  • G. S. Kenyon
  • P. McKelvie
Original Articles


Over the past 30 months, the authors have treated a wide variety of head and neck cancer patients with meta-tetrahydroxyphenylchlorin (mTHPC)-mediated photodynamic therapy (PDT). This drug is a powerful, second-generation photosensitizer with significant advantages over earlier drugs. Treatment ranged from palliation and adjunctive to curative procedures. Results to date are very encouraging, with marked advantages over standard methods of treatment with respect to morbidity, both functional and aesthetic. Potential cure rates remain essentially unchanged, very much dependent on the stage of the tumour. These promising early results justify a multicentre study for treatment of early head and neck cancer using this drug and light combination. This is now underway.

Key words

Photodynamic therapy Head and neck cancer Chlorin 


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Copyright information

© W.B. Saunders Company Ltd. 1996

Authors and Affiliations

  • M. G. Dilkes
    • 1
  • M. L. DeJode
    • 2
  • A. Rowntree-Taylor
    • 3
  • J. A. McGilligan
    • 1
  • G. S. Kenyon
    • 1
  • P. McKelvie
    • 1
  1. 1.ENT DepartmentThe Royal London HospitalWhitechapel, LondonUK
  2. 2.Surgical UnitThe Royal London HospitalWhitechapel, LondonUK
  3. 3.Scotia PharmaceuticalGuildfordUK

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