, Volume 11, Issue 6, pp 242–248 | Cite as

Influence de laβ-mercaptoéthylamine sur la réponse de l'intestin grêle du rat à une irradiation rœntgénienne localisée

  • P. Desaive
  • Josephine Varetto-Denoël
Informationen Studiorum Progressus


Intra-peritoneal injections of 15 mg of B-mercaptoethylamine in rats, with an average weight of 200 g, protect the small intestine against a local irradiation of 500 r on the antero-upper portion of the abdomen.

This protection is proved mainly, as compared with the control, by a smaller decrease of cells still in mitosis after 12 and 24 hours and of the migrant cells in resting stage, by a greater precocity and higher quantitative value of the post-radiation normal and subnormal mitotic processes, and by variations in the mitotic formula (namely, in protected animals, a relatively high increase in the amount of metaphases).

These experiments seem to prove a certain local and immediate action of the radio-protector, whose effects are not solely limited to the preparation of the generating system of the intestine for the later complete repair of the digestive epithelium.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    Z. M. Bacq, G. Dechamps, P. Fischer, A. Herve, H. le Biiian, J. Lecomte, M. Pirotte etP. Rayet, Science117, 633 (1953).PubMedGoogle Scholar
  2. 1.
    H. Betz, C. r. Soc. biol.1444, 593 (1950).Google Scholar
  3. 2.
    E. P. Cronkite, G. Brecher etW. H. Chapman, Proc. Soc. Exp. Biol. Med.76, 396 (1951).PubMedGoogle Scholar
  4. 3.
    J. H. Maisin, G. Lambert, M. Mandart etH. Maisin, Nature171, 971 (1953).Google Scholar
  5. 4.
    M. A. Gerebtzoff etZ. M. Bacq,Examen histopathologique de Souris irradiées après Cystéamine (sous presse).Google Scholar
  6. 5.
    R. L. Straube etH. M. Patt, Proc. Soc. Exp. Biol. Med.84, 702 (1953).PubMedGoogle Scholar
  7. 1.
    H. M. Patt, H. H. Vogel etJ. W. Clark, Proc. Soc. Exp. Biol. Med.84, 193 (1953).PubMedGoogle Scholar
  8. 2.
    P. Desaive, Communication 7e Congr. internat. Radiol., Copenhague 1953, Acta Radiologica41, 545 (1954).Google Scholar
  9. 3.
    P. Desaive, Z. M. Bacq etA. Herve, Science117, 633 (1953).PubMedGoogle Scholar
  10. 4.
    S. Chevremont, S. Comhaire etM. Chevremont, Arch. Biol.64, 399 (1953).Google Scholar
  11. 5.
    W. D. Kaplan etMary F. Lyon, Science118, 776, 777 (1953).PubMedGoogle Scholar
  12. 1.
    A. Herve etS. Neukomm, Commun. 7e Congr. internat. Radiol. Copenhague 1953.Google Scholar
  13. 2.
    P. Desaive, Communication 7e Congr. internat. Radiol., Copenhague 1953, Acta Radiologica41, 545 (1954).Google Scholar
  14. 3.
    P. Desaive, Z. Bacq etA. Herve, J. belge Radiol.36, 505 (1953).Google Scholar
  15. 4.
    H. Heinecke, Münch. Med. Wschr.51, 785 (1904).Google Scholar
  16. 5.
    Cl. Regaud, Th. Nogier etA. Lacassagne, Arch. Electr. Med.20, 321 (1912).Google Scholar
  17. 6.
    R. B. Engelstad, Strahlentherapie53, 139 (1935); Amer. J. Röntgenol.40, 243 (1938).Google Scholar
  18. 7.
    N. B. Friedman, Arch. Pathology34, 749 (1942).Google Scholar
  19. 8.
    N. B. Friedman, J. Exper. Med.81, 558 (1945).Google Scholar
  20. 9.
    B. Webber, B. R. Craig etN. B. Friedman, Cancer4, 1250 (1951).PubMedGoogle Scholar
  21. 1.
    A. P. Dustin, Bull. Assoc. Anatom.28, 249 (1932).Google Scholar
  22. 2.
    Warren etN. B. Friedman, cités parFriedman, J. Exper. Med.81, 558 (1945).Google Scholar
  23. 3.
    J. E. Kindred, J. Exp. Zoology121, 225 (1952).Google Scholar
  24. 4.
    P. Desaive, Communication 41e Réun. Anatom., Gênes, avril, 1954.Google Scholar

Copyright information

© Birkhäuser Verlag 1955

Authors and Affiliations

  • P. Desaive
  • Josephine Varetto-Denoël
    • 1
  1. 1.Université de LiègeBelgium

Personalised recommendations