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Influence de laβ-mercaptoéthylamine sur la réponse de l'intestin grêle du rat à une irradiation rœntgénienne localisée

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Summary

Intra-peritoneal injections of 15 mg of B-mercaptoethylamine in rats, with an average weight of 200 g, protect the small intestine against a local irradiation of 500 r on the antero-upper portion of the abdomen.

This protection is proved mainly, as compared with the control, by a smaller decrease of cells still in mitosis after 12 and 24 hours and of the migrant cells in resting stage, by a greater precocity and higher quantitative value of the post-radiation normal and subnormal mitotic processes, and by variations in the mitotic formula (namely, in protected animals, a relatively high increase in the amount of metaphases).

These experiments seem to prove a certain local and immediate action of the radio-protector, whose effects are not solely limited to the preparation of the generating system of the intestine for the later complete repair of the digestive epithelium.

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Authors and Affiliations

  1. Université de Liège, Belgium

    Josephine Varetto-Denoël

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  1. P. Desaive
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  2. Josephine Varetto-Denoël
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(Travail du Centre anticancéreux de l'Université de Liège et du Centre national belge pour l'étude de la croissance normale et pathologique).

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Desaive, P., Varetto-Denoël, J. Influence de laβ-mercaptoéthylamine sur la réponse de l'intestin grêle du rat à une irradiation rœntgénienne localisée. Experientia 11, 242–248 (1955). https://doi.org/10.1007/BF02160483

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