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Hydrolyse enzymatique de la propionylcholine, de l'acétylthiocholine et de la butyrylthiocholine par le rectus de grenouille

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Summary

The enzymatic hydrolysis of propionylcholine (PrCh), acetylthiocholine (AcThCh), and butyrylthiocholine (BuThCh), by extracts of the muscle rectus abdominis, was determined. Inhibition of this hydrolysis by D.F.P. and 3318 CT [bis(pipéridinométhylcoumaranyl- 5)cétone diméthiodide] — utilized over a range of concentrations covering both specific and non-specific concentrations—showed that PrCh is hydrolyzed by an acetylcholinesterase (70%) and an Xcholinesterase (30%), AcThCh by the AcChE (70%), the XChE (15%) and a thioesterase (15%) and BuThCh by the XChE (70%) and a thioesterase (30%).

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Authors and Affiliations

  1. Laboratoire de Pharmacologie, Service de Chimie Thérapeutique de l'Institut Pasteur, Paris

    J. Jacob & M. Pécot-Dechavassine

Authors
  1. J. Jacob
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  2. M. Pécot-Dechavassine
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Jacob, J., Pécot-Dechavassine, M. Hydrolyse enzymatique de la propionylcholine, de l'acétylthiocholine et de la butyrylthiocholine par le rectus de grenouille. Experientia 14, 330–332 (1958). https://doi.org/10.1007/BF02160391

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  • DOI: https://doi.org/10.1007/BF02160391

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