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De la réaction mitotique de l'épiderme de la tétine de cobaye à la suite d'applications répétées de diverses substances

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Summary

(1) The majority of substances tested produced a weaker mitotic reaction of the epidermis of the guinea pig nipple after 3 applications (24 h intervals) of the same substance than after a single application.

(2) This decrease in the ability of the epidermic cells to be divided has to be attributed, it seems, to a habit-forming processus and not to an exhaustion of the cells; indeed after two applications of geraniol, the application of a substance of different nature, Hormoestrol, produced in the nipple epidermis a mitotic flare up as intense as that obtained in the epidermis of a nipple not previously treated.

(3) Aldehyde C9 alone, among the substances tested, does not produce a decrease of epidermic mitoses after three applications but induces cellular alterations.

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References

  1. W. Jadassohn, E. Bujard, R. Firmenich etH. Isler,Scritti in onore del Prof. J. Cappelli (éd. Minerva Medica, Torino 1951).

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Authors and Affiliations

  1. Clinique de Dermatologie et Institut d'Histologie et d'Embryologie de l'Université de Genève, Switzerland

    E. Bujard, R. Brun & W. Jadassohn

Authors
  1. E. Bujard
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  2. R. Brun
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  3. W. Jadassohn
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Bujard, E., Brun, R. & Jadassohn, W. De la réaction mitotique de l'épiderme de la tétine de cobaye à la suite d'applications répétées de diverses substances. Experientia 14, 327–328 (1958). https://doi.org/10.1007/BF02160389

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  • DOI: https://doi.org/10.1007/BF02160389

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