Abstract
The effects of temperature on nerve-mediated or carbachol-induced contractions of isolated bovine iris-sphincter muscles were studied. A decrease in temperature (to below 36° C) led to contraction of the iris sphincter. The contractile responses induced by intramural cholinergic nerve stimulation were augmented by moderate cooling (29°–31° C), but were markedly inhibited by severe cooling (<22° C). On the other hand, after cooling the contractile amplitude induced by carbachol (3 × 10−7 M) was enhanced to 258% ± 16% (29°–31° C), and 185% ± 12% (20°–21° C) of control levels. Whereas the cooling-induced development of muscle tone was inhibited by the presence of indomethacin and FPL-55712, the application of prostaglandins (10−9 to 3 × 10−8 M) led to restoration of the sensitivity of the muscle observed at low temperatures. As low temperatures increase the response of bovine iris-sphincter muscle, temperature might affect the state of the iris during intraocular clinical surgery and in cases of intraocular inflammation.
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Suzuki, R., Yoshino, H., Teranishi, H. et al. Muscle tone and drug sensitivity of isolated bovine iris sphincter are enhanced at low temperatures. Graefe's Arch Clin Exp Ophthalmol 225, 137–140 (1987). https://doi.org/10.1007/BF02160346
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DOI: https://doi.org/10.1007/BF02160346