Abstract
We performed argon-laser iridotomy on pigmented rabbits and examined histologically the tissue of the anterior chamber angle, the iris, and the ciliary body. After laser iridotomy, 9/10 eyes showed an elevation in transient intraocular pressure. Deposits of blood plasma with fibrin were observed in the tissue of the circumferential anterior chamber angle from eyes enucleated at a period of high intraocular pressure. In the eyes in which ocular pressures returned to the baseline, the quantity of blood plasma was small. In the laser-irradiated iris and iris processes, cells constructing the vessel wall were degenerated, and blood plasma and fibrin exuded. In and around the ciliary body, fibrin was not demonstrated. These observations suggest that argon-laser irradiation to the iris leads to a breakdown of the blood-aqueous barrier mainly in the laser-treated iris, and that deposition of blood plasma with fibrin in the anterior chamber angle tissue may cause transient intraocular pressure elevations after laser iridotomy in rabbits.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chisholm IA, Grierson I (1977) Particulate phagocytosis by trabecular meshwork endothelium. Can J Ophthalmol 12:293–299
Epstein DL, Hashimoto JM, Grant WM (1978) Serum obstruction of aqueous outflow in enucleated eyes. Am J Ophthalmol 86:101–105
Greenidge KC, Rodrigues MM, Spaeth GL, Traverso CE, Weinreb S (1984) Acute intraocular pressure elevation after argon laser trabeculoplasty and iridectomy: a clinicopathologic study. Ophthalmic Surg 15:105–110
Grierson I, Chisholm IA (1978) Clearance of debris from the iris through the drainage angle of the rabbit's eye. Br J Ophthalmol 62:694–704
Hall CE (1963) Electron microscopy of the fibrinogen molecule and the fibrin clot. Lab Invest 12:998–1001
Ohnishi Y, Tanaka M (1981) Effects of pilocarpine and paracentesis on occluding junctions between the nonpigmented ciliary epithelial cells. Exp Eye Res 32:635–647
Okisaka S (1976a) Effects of paracentesis of the blood-aqueous barrier: a light and electron microscopic study on cynomolgus monkey. Invest Ophthalmol Vis Sci 15:824–834
Okisaka S (1976b) The effects of prostaglandin E1 on the ciliary epithelium and the drainage angle of cynomolgus monkeys: a light- and electron-microscopic study. Exp Eye Res 22:141–154
Perkins ES (1977) Prostaglandins and ocular trauma. Adv Ophthalmol 34:149–152
Pollack IP (1979) Use of argon laser energy to produce iridotomies. Trans Am Ophthalmol Soc 77:674–706
Pollack IP (1980) Use of argon laser energy to produce iridotomies. Ophthalmic Surg 11: 506–515
Pollack IP, Patz A (1976) Argon laser iridotomy: an experimental and clinical study. Ophthalmic Surg 7:22–30
Quigley HA (1981) Long-term follow-up of laser iridotomy. Ophthalmology 88:218–224
Robin AL, Pollack IP (1982) Argon laser peripheral iridotomies in the treatment of primary angle closure glaucoma. Long-term follow-up. Arch Ophthalmol 100:919–923
Robin AL, Pollack IP (1984) A comparison of neodymium: YAG and argon laser iridotomies. Ophthalmology 91:1011–1016
Robin AL, Pollack IP, Quigley HA, D'Anna S, Addicks EM (1982) Histologic studies of angle structures after laser iridotomy in primates. Arch Ophthalmol 100: 1665–1670
Rodrigues MM, Streeten B, Spaeth GL, Schwartz LW (1978) Argon laser iridotomy on primary angle closure or pupillary block glaucoma. Arch Ophthalmol 96:2222–2230
Schwartz LW, Rodrigues MM, Spaeth GL, Streeten B, Douglas C (1978) Argon laser iridotomy in the treatment of patients with primary angle-closure or pupillary block glaucoma: a clinicopathologic study. Ophthalmology 85:294–309
Sugino M, Tawara A, Inomata H (1984) Laser iridotomy for primary angle closure glaucoma. Folia Ophthalmol Jpn 35:248–253
Tripathi RC (1974) Comparative physiology and anatomy of the aqueous outflow pathway. In: Davson H, Graham LT Jr (eds) The eye, vol 5. Academic Press, New York, pp 163–356
Tripathi RC, Tripathi BJ (1972) The mechanism of aqueous outflow in lower mammals. Exp Eye Res 14:73–79
Unger WG, Bass MS (1977) Prostaglandin and nerve-mediated response of the rabbit eye to argon laser irradiation of the iris. Ophthalmologica 175:153–158
Unger WG, Perkins ES, Bass MS (1974) The response of the rabbit eye to laser irradiation of the iris. Exp Eye Res 19:367–377
Unger WG, Brown NAP, Edwards J (1977a) Response of the human eye to laser irradiation of the iris. Br J Ophthalmol 61:148–153
Unger WG, Cole DF, Bass MS (1977b) Prostaglandin and neurogenically mediated ocular response to laser irradiation of the rabbit iris. Exp Eye Res 25:209–220
Weinreb RN, Weaver D, Mitchell MD (1985) Prostanoids in rabbit aqueous humor. Effect of laser photocoagulation of the iris. Invest Ophthalmol Vis Sci 26:1087–1092
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tawara, A., Inomata, H. Histological study on transient ocular hypertension after laser iridotomy in rabbits. Graefe's Arch Clin Exp Ophthalmol 225, 114–122 (1987). https://doi.org/10.1007/BF02160342
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02160342