Abstract
A general review of the treatment ofCandida endophthalmitis is undertaken, with particular emphasis on the efficacy of various drugs currently in use. Their absorption by the eye when given systemically is also considered. The limitations of medical treatment for this condition are discussed and the theoretical reasons for vitrectomy considered. Six cases that underwent vitrectomy are reviewed, and the indications for vitrectomy in Candida endophthalmitis are discussed. A tentative overall plan for the management of such cases is given.
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Allansmith MR, Skaggs C, Kimur SH (1978) The diagnostic value of anterior chamber paracentesis in 14 cases of post operative endophthalmitis. Trans Am Ophthalmol Soc 68:335
Axelrod AJ, Peymann GA (1977) Intravitral amphotericin B. Treatment of experimental fungal endophalmitis. J Ophthalmol 76:584–588
Axelrod AJ, Peyman GA, Apple DJ (1973) Toxicity of intravitral injection of amphotericin B. Am J Ophtalmol 76:578–583
Blumenkranz MS, Stevens DA (1980) Therapy of endogenous fungal endophthalmitis. Arch Ophthalmol 98:1216–1220
Bossche H van der, Willemsen G, Cooks W, Cornelissen F, Van-Cutsen J (1978) Effects of ketaconazole on growth and lipid synthesis ofCandida albicans. Pre-clinical Research Report N15338. Jansenn Pharmaceutical R & D, New Brunswick, NJ
Cohen (1982) Antifungal chemotherapy. Lancet 532–537
Collignon PJ, Sorrell TC (1983) Disseminated candidiasis. Evidence of a distinctive syndrome in heroin abusers. Br Med J 287:861–862
Cosgrove RF, Beezer AE, Miles RJ (1978) In vitro studies of amphotericin B in combination with the imidazole antifungal compounds clortrimazole and miconazole. J Infect Dis 7:757
Cottingham AJ, Forster RK (1976) Vitrectomy in endophthalmitis. Arch Ophthalmol 94:2078
Edwards JE (1985)Candida endophthalmitis. In: Bodey GP, Fainstein V (eds) Candidiasis. Raven Press, New York, pp 211–225
Elliot JH, O'Day DM, Gutow GS, Poderski SF, Akrabawi P (1979) Mycotic endophthalmitis in drug abusers. Am J Ophthalmol 88:66–72
Getnick RA, Rodrigues MM (1974) Endogenous fungal endophthalmitis in a drug addict. Am J Ophthalmol 77:680
Goldberg A (1985) Committee on safety of medicines. January 1985
Green RW, Bennett JE, Goos RD (1965) Ocular penetration of amphotericin B. Arch Ophthalmol 73:769–775
Hamilton-Miller JM (1974) Fungal steroids and the mode of action of the polyene antibiotic. Adv Appl Microbiol 17:109–134
Kanski JJ (1970) Treatment of suppurative intraocular infection. Br J Ophthalmol 54:316
Kohner EM, Barry PJ (1984) Prevention of blindness in diabetic retinopathy. Diabetologia 26:173–179
Louria DB, Hensle T, Rose J (1967) The major medical complication of heroin addiction. Ann Intern Med 67:1
Maylath FR, Leopold FH (1955) Study of experimental intraocular infection. Am J Ophthalmol 40:86
McLeod D, Leaver PK (1977) Trampolines and triangles; the surgical pathology of the vitreous. Trans Ophthalmol Soc UK 97:225–231
Medoff G, Kobayashi GS (1980) Strategies in the treatment of systemic fungal infections. N Engl Med 302:145–155
Perraut LE Jr, Perraut LE, Bleiman B, Lyons J (1981) Successful treatment ofCandida albicans endophthalmitis with intravitral amphotericin B. Arch Ophthalmol 99:1565–1567
Polak A, Scholer HJ (1976) Combination of amphotericin B and 5-fluorocytosine. In: Williams JD, Geddes AM (eds) Chemotherapy, vol 6. Plenum Press, New York, pp 137–142
Robertson JR, Bucknall ABV, Welsby PD, Roberts JJK, Inglis JM, Peutherer JF, Brettle RP (1986) Epidemic of AIDS related virus (HLTV — III/LAV) infection among intravenous drug abusers. Br Med J 292:527–529
Salmon JF, Partridge BM, Spalton DJ (1983)Candida endophthalmitis in a heroin addict. A case report. Br J Ophthalmol 67:306
Sarosi GA, Parker JD, Dato IL, Tosh EE (1969) Amphotericin B in cryptococcal meningitis; long term results of treatment. Ann Intern Med 71:1079–1087
Servant JB, Dutton GN, Ong-Tone L, Barrie T, Davey C (1985)Candida encophthalmitis in Glaswegian heroin addicts. Report of an epidemic. Trans Ophthalmol Soc UK 104:297–308
Souri EN, Green WR (1974) Intravitral amphotericin B toxicity. Am J Ophthalmol 54:316
Stern GA, Fetkenhour GL, O'Grady RB (1977) Intravitral amphotericin B treatment ofCandida endophthalmitis. Arch Ophthalmol 95:89–93
Stone RD, Irvine AR, O'Connor GR (1975)Candida endophthalmitis; report of an unusual case with isolation of the etiological agent by vitreous biopsy. Ann Ophthalmol 7:757
Sugar HS, Mandell GH, Shalev JS (1971) Metastatic endophthalmitis associated with injection of addictive drugs. Am J Ophthalmol 71:1055
Takahashi M, Trempe CL, Maguire K, McMeel JW (1981) Vitreoretinal relationship in diabetic retinopathy; a biomicroscopic evaluation. Arch Ophthalmol 99:241–245
Tarr K (1980)Candida endophthalmitis and drug abuse. Aust J Ophthalmol 8:303
Titsworth E, Grunberg E (1973) Chemotherapeutic activity of 5-flucytosine and amphotericin B againstCandida albicans in mice: antimicrobial agents. Chemotherapy 4:306–308
Vastine DW, Horsley W, Guth SB, Goldberg MF (1976) EndogenousCandida endophthalmitis associated with heroin use. Arch Ophthalmol 94:1805
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Barrie, T. The place of elective vitrectomy in the management of patients withCandida endophthalmitis. Graefe's Arch Clin Exp Ophthalmol 225, 107–113 (1987). https://doi.org/10.1007/BF02160341
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DOI: https://doi.org/10.1007/BF02160341