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Neue Totalsynthese einer razemischen Doisynolsäure

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Summary

A new synthesis is described of a crystalline 7-methyl-doisynolic acid showing a strong estrogenic activity. This acid is probably identical with the stereoisomer Cα ofAnner andMiescher. Demethylation of this methoxyacid yields a new doisynolic acid of mp. 113–117° (hemihydrate).

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References

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Authors and Affiliations

  1. Forschungsinstitut für Pharmazie und Biochemie in Prag, Czechoslovakia

    M. Protiva, J. O. Jílek, E. Adlerová & L. Novák

Authors
  1. M. Protiva
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  2. J. O. Jílek
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  3. E. Adlerová
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  4. L. Novák
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Additional information

XIII. MitteilungSynthetische Versuche in der Gruppe der östrogenen Hormone; XII. Mitteilung siehe Chem. listy50, 2004 (1956).

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Protiva, M., Jílek, J.O., Adlerová, E. et al. Neue Totalsynthese einer razemischen Doisynolsäure. Experientia 13, 71–72 (1957). https://doi.org/10.1007/BF02160096

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