Advertisement

Experientia

, Volume 14, Issue 10, pp 377–378 | Cite as

Novobiocin as uncoupling agent

  • J. Frei
  • N. Canal
  • E. Gori
Kurze Mitteilungen

Keywords

Novobiocin Uncouple Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Les auteurs démontrent que la novobiocine provoque un découplement de l'oxydation phosphorylante dans un homogénat de foic de rat déjà à une concentration 1,575·10−4M. Les rapports entre l'activité antibactérienne et l'action biochimique de l'antibiotique sont discutés.

Literatur

  1. 1.
    R. D. Hotchkiss, Advanc. Enzymol.4, 153 (1944).Google Scholar
  2. 2.
    T. M. Brody andJ. A. Bain, J. Pharmacol.103, 338 (1951).Google Scholar
  3. 2a.
    T. M. Brody, R. Hurwitz, andJ. A. Bain, Antib. Chemother.4, 864 (1954).Google Scholar
  4. 3.
    R. B. Johnson, G. Feldott, andH. A. Lardy, Arch. Biochem.28, 317 (1950).PubMedGoogle Scholar
  5. 4.
    W. F. Loomis andF. Lipmann, J. Biol. Chem.173, 807 (1948).Google Scholar
  6. 5.
    H. W. Dalton, Lancet259, 596 (1950).CrossRefGoogle Scholar
  7. 5a.
    G. Ivanovics, Z. Immun. Forsch.102, 238 (1942).Google Scholar
  8. 5b.
    R. Lecoq, J. Solomides, andP. Landrin, Ann. pharm. franç.7, 326 (1949).Google Scholar
  9. 6.
    A. Marshak andJ. Hartig, J. cell. comp. Physiol.31, 321 (1948).CrossRefGoogle Scholar
  10. 7.
    T. M. Brody, R. Hurwitz, andJ. A. Bain, Antib. Chemother.4, 864 (1954).Google Scholar
  11. 8.
    M. Hamburger, J. Carleton, andM. Harcourt, Antib. Chemother.7, 274 (1957).Google Scholar
  12. 10.
    T. D. Brock, J. Bact.72, 320 (1956).PubMedGoogle Scholar
  13. 10a.
    H. Hoeksema, E. L. Caron, andJ. W. Hinman, J. Amer. Chem. Soc.78, 2019 (1956).CrossRefGoogle Scholar
  14. 11.
    E. Gori, R. C. Ist. lombardo86, 667 (1953).Google Scholar
  15. 12.
    C. Martius andD. Nitz-Ltzow, Biochim. biophys. Acta12, 134 (1953).CrossRefPubMedGoogle Scholar
  16. 12a.
    J. P. Green, E. Sondergaard, andH. Dam, J. Pharmacol.119, 12 (1957).Google Scholar
  17. 12b.
    U. Soderberg andC. A. Wachtmeister, J. Pharmacol.117, 298 (1956).Google Scholar
  18. 13.
    A. F. Brodie andC. T. Gray, J. Biol. Chem.219, 853 (1956).PubMedGoogle Scholar
  19. 13a.
    D. F. Hersey andS. J. Ajl, J. gen. Physiol.34, 295 (1951).CrossRefPubMedGoogle Scholar
  20. 13b.
    G. B. Pinchot, J. Biol. Chem.205, 65 (1953).PubMedGoogle Scholar
  21. 14.
    H. A. Krebs, A. Ruffo, M. Johnson, L. V. Eggleston, andR. Hems, Biochem. J.54, 107 (1953).PubMedGoogle Scholar
  22. 15.
    J. Frei, A. Vannotti, andP. Lerch, Exper.12, 193 (1956).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1958

Authors and Affiliations

  • J. Frei
    • 1
    • 2
  • N. Canal
    • 1
    • 2
  • E. Gori
    • 1
    • 2
  1. 1.Clinique Médicale UniversitaireLausanne
  2. 2.Istituto di Farmacologia dell'UniversitàMilano

Personalised recommendations