Advertisement

Experientia

, Volume 10, Issue 7, pp 298–300 | Cite as

Zur Kenntnis des Muscarins

  • C. H. Eugster
  • P. G. Waser
Kurze Mitteilungen

Summary

The alkaloid muscarin was isolated from fly agaric. The analyses of crystallized salts (chloride, tetra-chloroaurate,Reinecke's salt) led to C9H20O2N+ as the simplest formula. The presence of aldehyde and tri-methyl-ammonium groups, which had been assumed hitherto, could not be proved. The quaternary nature of the nitrogen atom was shown. Pharmacological tests on frog heart, rabbit gut and cats show the purely peripheral parasympathomimetic effect of the smallest doses.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    F. Kögl, H. Duisberg undH. Erxleben, Liebigs Ann. Chem.489, 156 (1931).Google Scholar
  2. 2.
    Siehe zum BeispielF. Kögl undH. Veldstra, Liebigs Ann. Chem.552, 1 (1942).Google Scholar
  3. 1.
    E. F. Rogers, D. Bovet, V. G. Longo undG. B. Marini-Bettolo, Exper.9, 260 (1953).Google Scholar
  4. 2.
    O. Schmiedeberg undE. Harnack, Arch. exp. Path. Pharm.6, 101 (1877).Google Scholar
  5. 1.
    F. Kögl undH. Veldstra, Liebigs Ann. Chem.552, 36 (1942).Google Scholar
  6. 2.
    H. King, J. Chem. Soc.1922, 1743.Google Scholar
  7. 3.
    H. Dale, J. Pharm. exp. Ther.6, 147 (1914).Google Scholar

Copyright information

© Birkhäuser Verlag 1954

Authors and Affiliations

  • C. H. Eugster
    • 1
  • P. G. Waser
    • 1
  1. 1.Chemisches Institut und Pharmakologisches Institut der Universität ZürichSwitzerland

Personalised recommendations