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Über einige pharmakologische Untersuchungen synthetischer Alkoxy-tropinderivate

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Summary

Some pharmacological properties of new synthetic alkoxy-tropine derivatives are reported. The tertiary compounds were relatively potent local anaesthetics with a low anti-cholinergic action. Acetylcholine inhibition, as well as the spasmolytic activityin vivo of the benzilic acid esters were markedly increased by quaternisation while their toxicity decreased. 6-Methoxytropine benzilic acid ester brom-methylate was the most active compound of this series. A pronounced inhibitory activity on neurogenically induced intestinal constriction was found in low doses, whereas larger doses exerted a ganglionic blocking effect.

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Authors and Affiliations

  1. Aus dem pharmakologischen Laboratorium der Sandoz AG., Basel

    E. Rothlin, M. Taeschler, H. Konzett & A. Cerletti

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  1. E. Rothlin
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  2. M. Taeschler
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  3. H. Konzett
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  4. A. Cerletti
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Rothlin, E., Taeschler, M., Konzett, H. et al. Über einige pharmakologische Untersuchungen synthetischer Alkoxy-tropinderivate. Experientia 10, 142–145 (1954). https://doi.org/10.1007/BF02158523

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  • DOI: https://doi.org/10.1007/BF02158523

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