Elektrolytgehalt von Endo- und Perilymphe in den einzelnen Schneckenwindungen des Meerschweinchens ohne und mit Stimulation

Summary

A freezing method is described which permits the measurement of electrolytes and enzymes in the peri- and endolymph from a single turn of the cochlea of guinea pig at a known time. The perilymphs of the scala vestibuli and the scala tympani are different, especially in the first basic turn. This difference may be produced by a partial semipermeability of the Reissner's membrane. After producing deafness by a sound of frequency 2000 c/s, the potassium (the total potassium level detected chemically and by the use of potassium-42) increases in the perilymph of the second turn only, and decreases slightly in the endolymph of the same turn. In the other turns, the potassium does not change.

This method permits the analysis of chemical changes due to the stimulus of single sounds.