Skip to main content
SpringerLink
Log in

Release of 5-hydroxytryptamine and histamine from neoplastic mast cells by alkaline tissue extracts

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Alkalische Extrakte diverser Rattengewebe setzen 5-Hydroxytryptamin (Serotonin) und Histamin aus Suspensionen neoplastischer Mastzellen der Maus frei. Gehirnund Nierenextrakte zeigen die grösste Aktivität. Zugabe von Glukose in die Nährlösung verhindert das Freiwerden der Amine. Eine vorläufige Charakterisierung des aktiven Materials ist unternommen worden.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. B. B. Brodie, in5-Hydroxytryptamine (Ed. by G. P. Lewis, Pergamon Press, New York and London 1958, p. 64.)

    Google Scholar 

  2. M. K. Paasonen andM. Vogt, J. Physiol.131, 617 (1956)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. C. C. Toh, J. Physiol.126, 248 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. C. C. Toh, J. Physiol.133, 402 (1956).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. C. C. Toh, J Physiol.138, 488 (1957).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. W. F. Scherer, Amer. J. Path.29, 113 (1953).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. J. L. Tullis, Blood6, 772 (1951).

    Google Scholar 

  8. A. H. Amin, T. B. B. Crawford, andJ. H. Gaddum, J. Physiol.126, 596 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. G. T. Archer, Nature182, 726 (1958).

    Article  CAS  PubMed  Google Scholar 

  10. R. Schindler, M. Day, andG. A. Fisher, Cancer Res.19, 47 (1959).

    CAS  PubMed  Google Scholar 

  11. W. D. M. Paton, Pharmacol. Rev.9, 269 (1957).

    CAS  PubMed  Google Scholar 

  12. B. Uvnas, J. Pharm. and Pharmacol.10, 13 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Yale University, School of Medicine, New Haven, Connecticut

    N. J. Giarman, L. T. Potter & Margaret Day

Authors
  1. N. J. Giarman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. T. Potter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Margaret Day
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Aided in part by grant B-940 from National Institute of Neurological Diseases and Blindness, and in part by the James Hudson Brown Memorial Fund of Yale Medical School.

This work was done in partial fulfillment of the requirements for the degree of Doctor of Medicine by L. T. P.

Squibb post-doctoral fellow in Pharmacology; present address, Department of Pharmacology, Royal College of Surgeons, London.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giarman, N.J., Potter, L.T. & Day, M. Release of 5-hydroxytryptamine and histamine from neoplastic mast cells by alkaline tissue extracts. Experientia 16, 492–494 (1960). https://doi.org/10.1007/BF02158355

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02158355

Keywords

Search

Navigation