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Antagonism against the arecoline tremors of oxyphenonium and its tertiary analogue after intravenous and intracerebral administration in mice

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Zusammenfassung

Die zentrale anticholinergische Wirkung von Oxyphenonium und seinem Analogon, der Substanz VUFB-3100, die tertiären Stickstoff im Molekül enthält, wurde bei intravenöser und intraventrikulärer Applikation geprüft. Die Wirkung von Oxyphenonium war bei intravenöser Verabreichung 48,5mal schwächer als diejenige von VUFB-3100, während bei Einführung der Substanz direkt in die laterale Hirnkammer nur unbedeutende Wirkungsunterschiede erzielt werden konnten.

Die Resultate passen zur Hypothese, wonach die schwächere zentrale anticholinergische Wirkung des Oxyphenoniums wahrscheinlich mit seiner schlechten Penetration durch die hämato-enzephalische Barriere zusammenhängt.

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Author notes

  1. E. V. Zejmal

    Present address: Institute of Evolution Physiology, Leningrad, USSR

Authors and Affiliations

  1. Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia

    E. V. Zejmal & Z. Votava

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  1. E. V. Zejmal
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  2. Z. Votava
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Zejmal, E.V., Votava, Z. Antagonism against the arecoline tremors of oxyphenonium and its tertiary analogue after intravenous and intracerebral administration in mice. Experientia 17, 471–472 (1961). https://doi.org/10.1007/BF02158300

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  • DOI: https://doi.org/10.1007/BF02158300

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