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Identification du glucosiduronate de 5β-pregnane 3α, 21-diol 20-one (THDOC) après administration de cortexone

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Summary

After administration of cortexone to a normal man, we isolated the 5β-pregnana 3α, 21-diol 20-one glucuronide in human urine. We found 90% of this corticosteroid in the glucuronide fraction; the remaining 10% was in the free fraction.

We found neither the cortexone nor its metabolites dior tetrahydrogenated in the ester-sulphate fraction.

The tetrahydrocortexone-glucuronide was identified by paper chromatography and by electrophoresis.

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Authors and Affiliations

  1. Laboratoire de Chimie Biologique, Faculté de Médecine, Paris, France

    J. R. Pasqualini & M. F. Jayle

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  1. J. R. Pasqualini
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  2. M. F. Jayle
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Pasqualini, J.R., Jayle, M.F. Identification du glucosiduronate de 5β-pregnane 3α, 21-diol 20-one (THDOC) après administration de cortexone. Experientia 17, 450–451 (1961). https://doi.org/10.1007/BF02158282

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  • DOI: https://doi.org/10.1007/BF02158282

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