Skip to main content
SpringerLink
Log in

16-β-methylprednisone from hecogenin

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Es wird über die Herstellung des 16-Methylprednisons berichtet, welche vom Hecogenin ausgehend über ca. 15 Stufen durchgeführt wird. Als wichtige Zwischenstufe treten 5α-Pregn-16-en-3β-ol-11, 20-dion-Acetat und 16-Methylen-5α-pregnan-3β, 17α-diol-11, 20-dion auf: letzteres wird durch eine stereospezifische katalytische Reduktion in das entsprechende 16β-Methyl-derivat umgewandelt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. D. Taub, R. D. Hoffsommer, H. L. Slates, C. H. Kuo, andN. L. Wendler, J. Amer. chem. Soc.82, 4012 (1960).

    Article  CAS  Google Scholar 

  2. G. Nominè, D. Bertin, andA. Pierdet, Tetrahedron8, 217 (1960).

    Article  Google Scholar 

  3. D. N. Kirk, V. Petrow, M. Stansfield, andD. M. Williamson, J. chem. Soc.1960, 2385.

  4. E. M. Chamberlain, W. V. Ruyle, A. E. Erickson, J. M. Chemerda, L. M. Aliminosa, R. L. Erickson, G. E. Sita, andM. Tishler, J. Amer. chem. Soc.73, 2396 (1951).

    Article  Google Scholar 

  5. C. Djerassi, E. Batres, J. Romo, andG. Rosenkranz, J. Amer. chem. Soc.74, 3634 (1952).

    Article  CAS  Google Scholar 

  6. A. F. B. Cameron, R. M. Evans, J. C. Hamlett, J. S. Hunt, P. G. Jones, andA. G. Long, J. chem. Soc.1955, 2807.

  7. P. De Ruggieri, Farmaco, Ed. sci.16, 58 (1961).

    Google Scholar 

  8. K. Heusler, J. Kebrle, C. Meystre, H. Ueberwasser, P. Wieland, G. Anner, andA. Wettstein, Helv. chim. Acta42, 42, 2043 (1959).

    Article  CAS  Google Scholar 

  9. K. Bowden, I. M. Heilbron, E. R. H. Jones, andB. C. L. Weedon, J. chem. Soc.1946, 39.

  10. R. Joly, J. Warnant, G. Nominè, andD. Bertin, Bull. Soc. chim. Fr. [5]15, 366 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Laboratories of Lepetit S.p.A., Milano, Italy

    G. G. Nathansohn, G. Winters & E. Testa

Authors
  1. G. G. Nathansohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Winters
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Testa
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nathansohn, G.G., Winters, G. & Testa, E. 16-β-methylprednisone from hecogenin. Experientia 17, 448–449 (1961). https://doi.org/10.1007/BF02158280

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02158280

Keywords

Search

Navigation