Summary
By means of guinea-pig auricle preparations, which were damaged in some way, it was demonstrated that bufadienolids compensate different model ‘insufficiences’ more efficaciously than cardenolids; and 3,14,12-trihydroxygenins more efficaciously than 3,14-dihydroxygenins, and even better than 3,14,16-trihydroxygenins.
References
W. Förster, Exper.17, 220 (1961).
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Förster, W. Weitere Untersuchungen über strukturabhängige Wirkungsunterschiede bei Cardenoliden und Bufadienoliden. Experientia 17, 308–309 (1961). https://doi.org/10.1007/BF02158170
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DOI: https://doi.org/10.1007/BF02158170