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Reserpin und Glykogengehalt der Organe

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Summary

In fasted white mice, 1–18 h after the injection of 5 mg/kg Reserpine the glycogen content of brain, heart, skeletal muscle and liver is significantly increased (about 100%, in liver nearly 300%). It is suggested that this is due to an enhanced synthesis of glycogen from non-carbohydrate material.

Concerning the underlying mechanism, it is pointed out that after reserpine there occurs a release of catecholamines from the adrenal medulla and-by stimulation of the anterior pituitary-an enhanced production of corticoids.

Simultaneously with the increase of the brain glycogen, the level of lactic acid is decreased, whereas the ATP-, ADP- and AMP-content of the brain remains practically unaffected.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Frankfurt a. M., Deutschland

    H. Balzer, P. Holtz & D. Palm

Authors
  1. H. Balzer
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  2. P. Holtz
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  3. D. Palm
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Ausgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Balzer, H., Holtz, P. & Palm, D. Reserpin und Glykogengehalt der Organe. Experientia 17, 304–305 (1961). https://doi.org/10.1007/BF02158166

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