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Experientia

, Volume 17, Issue 7, pp 297–298 | Cite as

Stereochemical and polar effects in bromination of androstan-3-one mannich bases

  • G. deStevens
  • Angela Halamandaris
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Keywords

Polar Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Mannich-Basen von 5α-Androstan-3-one wurden unter thermodynamisch und kinetisch kontrollierten Bedingungen bromiert. Die Konformation der unter diesen Bedingungen erhaltenen Produkte wurde stark durch die sterischen und polaren Eigenschaften des Substituenten in 2-Stellung beeinflusst.

References

  1. 1.
    G. DeStevens andA. Halamandaris, J. org. Chem.26, 1614 (1961).Google Scholar
  2. 2.
    C. Djerassi, N. Finch, R. C. Cookson andC. W. Bird, J. Amer. chem. Soc.82, 5488 (1960).Google Scholar
  3. 3.
    R. Mauli, H. J. Ringold andC. Djerassi, J. Amer. chem. Soc.82, 5494 (1960).Google Scholar
  4. 4.
    The authors are indebted to ProfessorR. K. Hill, Princeton University, Princeton (N. J.), for carrying out this determination.Google Scholar
  5. 5.
    R. Villotti, H. J. Ringold, andC. Djerassi, J. Amer. chem. Soc.82, 5693 (1960).Google Scholar

Copyright information

© Birkhäuser Verlag 1961

Authors and Affiliations

  • G. deStevens
    • 1
  • Angela Halamandaris
    • 1
  1. 1.Chemical Research DivisionCIBA Pharmaceutical Products Inc.Summit

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