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Identification of human serum proteins binding iron, copper, and thyroid hormones by starch gel electrophoresis

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Résumé

On a analysé au moyen d'électrophorèse sur gel d'amidon les protéines qui, dans le sérum humain, lient le fer, le cuivre et l'hormone thyroïdienne, en utilisant comme témoins des protéines purifiées et la radioactivité. Le fer est lié par la β-globuline qui, dans certaines familles, paraît se diviser en deux composants. Le cuivre est lié par la céruloplasmine, qui émigre dans la position α2 rapide. La protéine principale liant la thyroxine est la préalbumine.

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References

  1. O. Smithies, Biochem. J.61, 629 (1955).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. M. D. Poulik, Nature180, 1477 (1957).

    Article  CAS  PubMed  Google Scholar 

  3. M. D. Poulik andO. Smithies, Biochem. J.68, 636 (1958).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. H. J. Silberman, Biochim. biophys. Acta24, 641 (1957).

    Article  Google Scholar 

  5. J. M. Fine andM. Burstein, Exper.14, 411 (1958).

    CAS  Google Scholar 

  6. R. L. Engle, Jr., K. R. Woods, andJ. H. Pert, J. clin. Invest.36, 888 (1957).

    Google Scholar 

  7. K. Schmid, J. Amer. chem. Soc.72, 2816 (1950).

    Article  CAS  Google Scholar 

  8. H. E. Weimer, J. W. Mehl, andR. J. Winzler, J. biol. Chem.185, 561 (1950).

    Article  CAS  PubMed  Google Scholar 

  9. C. B. Laurell, andB. Ingelman, Acta chem. scand.1, 770 (1947).

    Article  Google Scholar 

  10. J. L. Oncley, G. Scatchard, andA. Brown, J. Phys. coll. Chem.51, 184 (1947).

    Article  CAS  Google Scholar 

  11. H. E. Schade, Schade, R. W. Reinhart, andH. Levy, Arch. Biochem.2, 170 (1949).

    Google Scholar 

  12. E. J. Cohn, Ann. int. Med.26, 341 (1947).

    Article  CAS  PubMed  Google Scholar 

  13. H. E. Schultze, K. Heide, andH. Muller, Behringwerk-Mitt. No. 32, 24 (1957).

  14. O. Smithies, Nature180, 1482 (1957).

    Article  CAS  PubMed  Google Scholar 

  15. W. R. Horsfall andO. Smithies, Science128, 35 (1958).

    Article  CAS  PubMed  Google Scholar 

  16. O. Smithies, Nature181, 1203 (1958).

    Article  CAS  PubMed  Google Scholar 

  17. H. Harris, E. B. Robson, andM. Siniscalco, Nature182, 452 (1958).

    Article  CAS  PubMed  Google Scholar 

  18. M. D. Poulik, Nature177, 982 (1956).

    Article  CAS  PubMed  Google Scholar 

  19. O. Smithies, personal communication.

  20. V. M. Ingram, Nature180, 326 (1957).

    Article  CAS  PubMed  Google Scholar 

  21. J. A. Hunt andV. M. Ingram, Nature181, 1062 (1958).

    Article  CAS  PubMed  Google Scholar 

  22. O. Smithies andC. G. Hickman, Genetics43, 374 (1958).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. C. G. Ashton, Nature180, 917 (1957);181, 849 (1958);182, 193 (1958);182, 1029 (1958).

    Article  CAS  PubMed  Google Scholar 

  24. A. G. Bearn andH. G. Kunkel, J. Lab. clin. Med.45, 623.

  25. A. G. Bearn, Amer. J. Med.22, 747 (1957).

    Article  CAS  PubMed  Google Scholar 

  26. C. G. Holmberg andC.-B. Laurell, Acta chem. scand.2, 550 (1948).

    Article  CAS  Google Scholar 

  27. J. de Grouchy, Rev. franç. Etudes clin. biol.3, 621 (1958).

    Google Scholar 

  28. J. Uriel, Bull. Soc. Chim. biol., Suppl.1, 105 (1957).

    Google Scholar 

  29. J. Robbins andJ. E. Rall, Rec. Adv. Hormone Res.13, 161 (1957).

    CAS  Google Scholar 

  30. J. Robbins, J. E. Rall, andM. L. Peterman, J. clin. Invest.36, 1333 (1957).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. C. Rich andA. G. Bearn, Endocrinology62, 687 (1958).

    Article  CAS  PubMed  Google Scholar 

  32. S. H. Ingbar, Endocrinology63, 256 (1958).

    Article  CAS  PubMed  Google Scholar 

  33. J. Tata, Nature183, 877 (1959).

    Article  CAS  PubMed  Google Scholar 

  34. H. E. Schultze, M. Schonberger, andG. Schwick, Biochem. Z.328, 267 (1956).

    CAS  PubMed  Google Scholar 

  35. W. G. Gratzer, personal communication.

  36. Unpublished observations byD. R. Bangham, J. Tata, andA. C. Allison.

  37. C. Osorio andN. B. Myant, Nature182, 866 (1958).

    Article  CAS  PubMed  Google Scholar 

  38. W. P. Deiss, E. C. Albright, andF. C. Larson, J. clin. Invest.33, 320 (1954).

    Google Scholar 

  39. J. Robbins, J. E. Rall, andR. W. Rawson, J. clin. Endocrinol.15, 1315 (1955).

    Article  CAS  Google Scholar 

  40. L. J. De Groot, S. Postel, J. Litvak, andJ. B. Stanbury, J. clin. Endocrinol.18, 158 (1958).

    Article  Google Scholar 

  41. C. Cameron andK. Fletcher, Nature183, 116 (1959).

    Article  CAS  PubMed  Google Scholar 

  42. J. Tata, J. E. Rall, andR. W. Rawson, J. clin. Endocrinol.16, 1554 (1956).

    Article  CAS  Google Scholar 

  43. W. P. Deiss, E. C. Albright, andF. C. Larson, J. clin. Invest.31, 1000 (1952).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Y. Derrien, R. Michel, K. Pedersen, andJ. Roche, Biochim. biophys. Acta3, 436 (1949).

    Article  CAS  Google Scholar 

  45. I. J. O'Donnell, R. L. Baldwin, andJ. W. Williams, Biochim. biophys. Acta28, 294 (1958).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. National Institute for Medical Research, London

    A. C. Allison

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  1. A. C. Allison
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Allison, A.C. Identification of human serum proteins binding iron, copper, and thyroid hormones by starch gel electrophoresis. Experientia 15, 281–284 (1959). https://doi.org/10.1007/BF02158085

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