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Studio farmacologico di un nuovo coleretico derivato dall'acidoα-cicloesil butirrico

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Summary

α-(1-Hydroxy-4-phenyl-cyclohexyl)butyric acid (M. G. 4833) andα-(1-hydroxy-3-phenyl-cyclohexyl) butyric acid (M. G. 4834) have been synthesized; both substances were endowed with choleretic activity.

M. G. 4833 is the more active; it acts at lower doses and for a longer time than sodium dehydrocholate on rats, rabbits and dogs submitted to temporary fistulization of the bile-duct.

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References

  1. J. Maillard, M. Benard eR. Morin, Bull. Soc. Chim. France1958, 244.

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Authors and Affiliations

  1. Laboratori Ricerche Maggioni & C., Milano

    M. Carissimi, F. Ravenna, E. Milla & E. Grumelli

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  1. M. Carissimi
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  2. F. Ravenna
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  3. E. Milla
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  4. E. Grumelli
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Carissimi, M., Ravenna, F., Milla, E. et al. Studio farmacologico di un nuovo coleretico derivato dall'acidoα-cicloesil butirrico. Experientia 15, 262–264 (1959). https://doi.org/10.1007/BF02158073

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  • DOI: https://doi.org/10.1007/BF02158073

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