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The metabolism of 3-hydroxytyramine-1-C14 in brain tissue homogenates

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Zusammenfassung

Homogenate aus Gehirn wurden mit 3-Hydroxytyramine-1-C14 inkubiert. Als Stoffwechselprodukt wurde aus der sauren Fraktion radioaktive 3,4-Dioxyphenylessigsäure isoliert. Aus der basischen Fraktion wurden drei radioaktive Zonen papierchromatographisch isoliert. Die erste Zone konnte noch nicht identifiziert werden. Die zweite wurde als 3-Hydroxytyramin und die dritte als 3-Methoxytyramin erkannt. Die mögliche Rolle der Stoffwechselprodukte von 3-Hydroxytyramin beim Parkinson-Syndrom wird diskutiert.

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References

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Authors and Affiliations

  1. Department of Psychiatry and Neurology, Psychopharmacology Research Unit, New York University College of Medicine, New York

    M. Goldstein, A. J. Friedhoff, C. Simmons & N. N. Prochoroff

Authors
  1. M. Goldstein
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  2. A. J. Friedhoff
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  3. C. Simmons
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  4. N. N. Prochoroff
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Additional information

This study was supported in part by United States Public Health Service Grant M 2717.

The authors are grateful toR. J. Floody, M. D. of Hoffmann-La Roche Inc., for providing us with iproniazid.

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Goldstein, M., Friedhoff, A.J., Simmons, C. et al. The metabolism of 3-hydroxytyramine-1-C14 in brain tissue homogenates. Experientia 15, 254–256 (1959). https://doi.org/10.1007/BF02158068

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