Summary
Based on the behaviour of lecithin in a biophysical cell model, novel compounds have been developed which are regarded as ‘phosphatide blockers’ in the membrane of the living cell. They inhibit neoplasms in animal experiments to a high degree, and are therefore potential chemotherapeutic agents of great interest.
References
R. Hirt undR. Berchtold, Med. exp.2, 269 (1960).
Ch. Wiegand, inHouben-Weyl,Methoden der organischen Chemie, 3. Aufl. (Stuttgart 1955), Bd. 3/1, p. 681.
D. Vorländer,Chemische Kristallographie der Flüssigkeiten (Leipzig 1924).
C. Weygand, Hand- und Jahrbuch der chemischen Physik, 2 (Leipzig 1941).
Ch. R. Wiegand, Z. Naturforsch.12b, 512 (1957).
J. V. A. Butler, G. N. Godson undG. D. Hunter, inR. J. C. Harries,Protein Biosynthesis (Academic Press, London 1961).
G. E. Hunter undG. N. Godson, Nature189, 140 (1961).
R. W. Hendler, J. biol. Chem.234, 1466 (1959).
W. L. Gaby undR. Silberman, Arch. Biochem. Biophys.87, 188 (1960).
G. N. Godson undG. D. Hunter, Biochem. J.79, 37 P (1961).
H. Fischer undK. Röwe, Trans. 6th Congr. Europ. Soc. Haematology (Copenhagen 1957), p. 927.
M. S. Steinberg, Amer. Naturalist92, 65 (1958).
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Hirt, R., Berchtold, R. Biophysikalische Studien mit synthetischem Lecithin als Weg zu neuartigen Chemotherapeutika. Experientia 17, 418–420 (1961). https://doi.org/10.1007/BF02157981
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DOI: https://doi.org/10.1007/BF02157981