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Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil)

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Zusammenfassung

Nach Verabreichung von Imipramin (Tofranil) wurde aus dem Gehirn von Ratten Desmethylimipramin, das N-Monomethylderivat, isoliert. Dieser Metabolit beziehungsweise dessen Anreicherungin vivo scheint für die antidepressive Wirkung von Imipramin verantwortlich zu sein.

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References

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Authors and Affiliations

  1. Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

    J. R. Gillette, J. V. Dingell, F. Sulser, R. Kuntzman & B. B. Brodie

Authors
  1. J. R. Gillette
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  2. J. V. Dingell
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  3. F. Sulser
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  4. R. Kuntzman
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  5. B. B. Brodie
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Additional information

Presented in part as an abstract in Fed. Proc.20, 321 (1961). Some of the material in this communication is taken from a dissertation byJ. V. Dingell to be submitted to the Graduate School of Georgetown University in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

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Gillette, J.R., Dingell, J.V., Sulser, F. et al. Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil). Experientia 17, 417–418 (1961). https://doi.org/10.1007/BF02157980

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  • DOI: https://doi.org/10.1007/BF02157980

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