Summary
1. In mice,reserpine (5 mg/kg) causes a long-lasting depletion of the brain for γ-aminobutyric acid (GABA), which corresponds temporally to the lowered seizure threshold (electroshock).
2.Iproniazid prohibits both the depletion of GABA and the lowering of seizure threshold.
3. Relations between amine- and GABA-metabolism of the brain are pointed out.
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References
A. Goldin, D. Dennis, J. Venditti undS. Humphreys, Science121, 364 (1955).
J. R. Fouts undB. B. Brodie, J. Pharmacol. exp. Therap.116, 480 (1956).
F. M. Sturtevant, Naturwissensch.43, 67 (1956).
G. Chen, C. R. Ensor undB. Bohner, Proc. Soc. exp. Biol. Med., N. Y.86, 507 (1954).
B. B. Brodie, J. S. Olin, R. G. Kuntzman undP. H. Shore, Science125, 1293 (1957).
B. B. Brodie, A. Pletscher undP. A. Shore, J. Pharmacol. exp. Therap.116, 9 (1956).
P. Holtz, H. Balzer, E. Westermann undE. Wezler, Arch. exp. Path. Pharmak.231, 333 (1957).
W. Kobinger, Arch. exp. Path. Pharmak.233, 559 (1958).
P. A. Shore, S. L. Silver undB. B. Brodie, Science122, 284 (1955).
E. H. Jenney undC. C. Pfeiffer, J. Pharmacol. exp. Therap.122, 110 (1958).
K. F. Killam undJ. A. Bain, J. Pharmacol. exp. Therap.119, 255 (1957).
H. Balzer, P. Holtz undD. Palm, Arch. exp. Path. Pharmak.,239, 520 (1960).
H. Grundfest,Inhibition in the Nervous System and γ-Aminobutyric Acid (Pergamon Press, New York 1960), p. 47.
J. T. Litchfield undF. Wilcoxon, J. Pharmacol. exp. Therap.96, 99 (1949).
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Balzer, H., Holtz, P. & Palm, D. Reserpin und γ-Aminobuttersäuregehalt des Gehirns. Experientia 17, 38–40 (1961). https://doi.org/10.1007/BF02157943
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DOI: https://doi.org/10.1007/BF02157943