Skip to main content
SpringerLink
Log in

Über eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika Sideromycine

  • Published:
Experientia Aims and scope Submit manuscript

Summary

A new group of iron-containing metabolites, with growth stimulating properties for a number of microorganisms, has been isolated from streptomycetes and namedferrioxamines. It is proposed to include them, together with some known substances, like ferrichrome, coprogen and the terregens factor, which either contain or bind iron, in a new class of growth factors, thesideramines.

The biological property of the sideramines is counteracted by iron-containing antibiotics from streptomycetes, thesideromycins. They comprise, besides known products like grisein and albomycin, two new groups of antibiotics, among them the highly potentferrimycins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. Zähner, R. Hütter undE. Bachmann, Arch. Mikrobiol., im Druck (1960).

  2. D. M. Reynolds, A. Schatz undS. A. Waksman, Proc. Soc. exp. Biol. Med., N. Y.64, 50 (1947).

    Article  CAS  Google Scholar 

  3. D. M. Reynolds undS. A. Waksman, J. Bact.55, 739 (1948).

    Article  CAS  Google Scholar 

  4. F. A. Kuehl, M. N. Bishop, L. Chaiet undK. Folkers, J. Amer. chem. Soc.73, 1770 (1951).

    Article  CAS  Google Scholar 

  5. G. F. Gause undM. G. Brazhnikova, Nov. Med. (Moskau)23, 3 (1951).

    Google Scholar 

  6. G. F. Gause, Brit. med. J.1955, 1177.

  7. E. S. Kudrina undG. V. Kochetkova, Antibiotiki (Moskau)3, 63 (1958).

    CAS  Google Scholar 

  8. E. O. Stapley undR. E. Ormond, Science125, 587 (1957).

    Article  CAS  Google Scholar 

  9. M. G. Brazhnikova, O. Mikeš undN. N. Lomakina, Biochimija (Moskau)22, 111 (1957).

    CAS  Google Scholar 

  10. O. Mikeš undF. Šorm, Symposium on Antibiotics, Prag (1959), 30.

  11. H. Thrum, Naturwiss.44, 561 (1957).

    Article  CAS  Google Scholar 

  12. P. Sensi undM. T. Timbal, Antibiotics & Chemotherapy9, 160 (1959).

    CAS  Google Scholar 

  13. Wir danken Dr.K. Folkers, Merck & Co., Inc., Rahway, N. J., USA., und Dr.H. Thrum, Jena, für die Überlassung von Vergleichsproben.

  14. J. B. Neilands, J. Amer. chem. Soc.74, 4846 (1952); J. biol. Chem.205, 643, 647 (1953); Bact. Rev.21, 101 (1957).

    Article  CAS  Google Scholar 

  15. J. A. Garibaldi undJ. B. Neilands, J. Amer. chem. Soc.77, 2429 (1955).

    Article  CAS  Google Scholar 

  16. C. W. Hesseltine, C. Pidacks, A. R. Whitehall, N. Bohonos, B. L. Hutchings undJ. H. Williams, J. Amer. chem. Soc.74, 1362 (1952).

    Article  CAS  Google Scholar 

  17. C. W. Hesseltine, A. R. Whitehill, C. Pidacks, M. T. Hagen, N. Bohonos, B. L. Hutchings undJ. H. Williams, Mycologia45, 7 (1953).

    Article  Google Scholar 

  18. C. Pidacks, A. R. Whitehill, L. Pruess, C. W. Hesseltine, B. L. Hutchings, N. Bohonos undJ. H. Williams, J. Amer. chem. Soc.75, 6064 (1953).

    Article  CAS  Google Scholar 

  19. A. G. Lochhead, M. O. Burton undR. H. Thexton, Nature170, 282 (1952).

    Article  CAS  Google Scholar 

  20. A. G. Lochhead undM. O. Burton, Canad. J. Botany31, 7 (1953).

    Article  Google Scholar 

  21. M. O. Burton, F. J. Sowden undA. G. Lochhead, Canad. J. Biochem. Physiol.32, 400 (1954).

    Article  CAS  Google Scholar 

  22. Wir möchten in diesem Zusammenhang Prof.J. B. Meilands, Berkeley, California, für die Überlassung von Präparaten und Prof.A. G. Lochhead, Ottawa, Kanada, für die Zusendung von Kulturen danken.

  23. Vgl. auchA. L. Demain undD. Hendlin, J. gen. Microbiol.21, 72 (1959).

    Article  CAS  Google Scholar 

  24. J. Francis, H. M. Macturk, J. Madinaveitia undG. A. Snow, Biochem. J.55, 596 (1953).

    Article  CAS  Google Scholar 

  25. G. A. Snow, J. chem. Soc.1954, 2588, 4080.

  26. H. Bickel et al., Helv. chim. Acta, in Vorbereitung.

  27. L. Neipp et al., in Vorbereitung.

  28. T. Emery undJ. B. Neilands, Nature184, 1632 (1959).

    Article  CAS  Google Scholar 

  29. T. Z. Csáky, Acta chem. scand.2, 450 (1948).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmazeutische Abteilung, Forschungslaboratorien der CIBA Aktiengesellschaft, Basel

    H. Bickel, E. Vischer & A. Wettstein

  2. Institut für spezielle Botanik der ETH, Zürich

    E. Gäumann & H. Zähner

  3. Organisch-chemisches Laboratorium der ETH, Zürich

    W. Keller-Schierlein & V. Prelog

Authors
  1. H. Bickel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Gäumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Keller-Schierlein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Prelog
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Vischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Wettstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. Zähner
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

22. Mitteilung, Stoffwechselprodukte von Actinomyceten; 21. Mitteilung: Helv. chim. acta43, im Druck (1960).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bickel, H., Gäumann, E., Keller-Schierlein, W. et al. Über eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika Sideromycine. Experientia 16, 129–133 (1960). https://doi.org/10.1007/BF02157712

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02157712

Search

Navigation