Zusammenfassung
Dregamine, ein neues Alkaloid aus der ApocynaceaeVoacanga dregei E. M. wurde isoliert und charakterisiert. Diese Verbindung stellt einen neuen Vertreter der Klasse der 2-Acyl-indole dar.
References
After the completion of this work,Schuler, Verbeek, andWarren, J. chem. Soc.1958, 4776, have reported the isolation of the known alkaloids vobtusine and voacangine from the bark ofVoacanga dregei collected in the South Coast, Natal, S. Africa. We were unable to find these alkaloids in our plant material.
M. Gorman, N. Neuss, andN. J. Cone, Amer. chem. Soc. nat. Meeting, San Francisco, Calif., April 1958. The spectral data reported for voacafrine and voacafricine [K. V. Rao, J. org. Chem.23, 1455 (1958)] are also indicative of the presence of a 2-acyl indole moiety in these two alkaloids fromVoacanga africana.
Small amounts of this alkaloid were also isolated fromErvatamia coronaria 3.
Subsequent to the preparation of this manuscript,Renner has described the isolation of vobasine and voacryptine fromV. africana. The former alkaloid appears to be another representative of 2-acyl indoles3 [U. Renner, Exper.15, 185 (1959)].
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Alkaloids of Apocynaceae III,M. Gorman, N. Neuss, J. A. Deyrup, andN. J. Cone, J. Amer. chem. Soc. (1959), in press.
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Neuss, N., Cone, N.J. Alkaloids of apocynaceae IV. Dregamine, a new alkaloid fromVoacanga dregei E. M.. Experientia 15, 414–415 (1959). https://doi.org/10.1007/BF02157683
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DOI: https://doi.org/10.1007/BF02157683