Eigenschaften der Adenovirus-Hämagglutinine

  • H. Bauer
  • R. Wigand


Adenovirus hemagglutinins were classified into five groups designated as A to E according to differences in heat stability, sensitivity to trypsin treatment or to trypsin plus subsequent heating, adsorption of hemagglutinin and infectious virus to red cells and separation of hemagglutinin from infectious virus by ultracentrifugation. These properties are summarized in Table 12. Hemagglutination by A hemagglutinin is demonstrable only in the presence of heterologous adenovirus immune serum, probably of all serotypes. Hemagglutinin A may modify red cell receptors in absence of heterologous serum; these receptors appear to be different from those involved in hemagglutination by myxoviruses. The mechanism of hemagglutination by the various hemagglutinins is discussed.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allison, A. C., H. G. Pereira andC. P. Farthing: Investigation of adenovirus antigens by agar gel diffusion techniques. Virology10, 316–328 (1960).PubMedGoogle Scholar
  2. Bauer, H., u.R. Wigand: Heterogeneity of adenovirus hemagglutinins. Arch. ges. Virusforsch.12, 148–151 (1962).PubMedGoogle Scholar
  3. Bell, S. D., jr.,T. R. Rota andD. E. McComb: Adenovirusses isolated from Saudi Arabia. III. Six new serotypes. Amer. J. trop. Med. Hyg.9, 523–526 (1960).Google Scholar
  4. Buckland, F. E.: Impairment of viral haemagglutination of red cells after treatment with formalin. Nature (Lond.)183, 1276 (1959).Google Scholar
  5. —: Inactivation of virus haemagglutinins by para-chloromercuribenzoic acid. Nature (Lond.)188, 768 (1960).Google Scholar
  6. Fastier, L. B.: Studies on the hemagglutinin of infectious canine hepatitis virus. J. Immunol.78, 413–418 (1957).PubMedGoogle Scholar
  7. Kasel, J. A., W. P. Rowe andJ. L. Nemes: Modification of erythrocyte receptors by a factor in adenovirus suspensions. Virology10, 388–391 (1960).PubMedGoogle Scholar
  8. — — —: Further characterization of the adenovirus erythrocyte receptor-modifying factor. J. exp. Med.114, 717–728 (1961).PubMedGoogle Scholar
  9. Nász, I., A. Lengyel, P. Dán andG. Kulcsár: Informative studies on the haemagglutination spectra of adenoviruses. Acta microbiol. Acad. Sci. hung.9, 69–76 (1962).PubMedGoogle Scholar
  10. Pereira, H. G.: A virus inhibitor produced in HeLa cells infected with adenovirus. Virology11, 590–602 (1960).PubMedGoogle Scholar
  11. —,A. C. Allison andC. P. Farthing: Study of adenovirus antigens by immunoelectrophoresis. Nature (Lond.)183, 895–896 (1959).Google Scholar
  12. —, andM. V. T. de Figueiredo: Mechanism of hemagglutination by adenovirus types 1, 2, 4, 5, and 6. Virology18, 1–8 (1962).PubMedGoogle Scholar
  13. Rosen, L.: A hemagglutination-inhibition technique for typing of adenoviruses. Amer. J. Hyg.71, 120–128 (1960).PubMedGoogle Scholar
  14. —,S. Baron andJ. A. Bell: Four newly recognized adenoviruses. Proc. Soc. exp. Biol. (N. Y.)107, 434–437 (1961).Google Scholar
  15. Rowe, W. P., J. W. Hartley andR. J. Huebner: Serotype composition of the adenovirus group. Proc. Soc. exp. Biol. (N. Y.)97, 465–470 (1958).Google Scholar
  16. Simon, M.: Haemagglutination experiments with certain adenovirus type strains. Acta microbiol. Acad. Sci. hung.9, 45–54 (1962a).PubMedGoogle Scholar
  17. —: Chromatography of adenoviruses on calcium phosphate columns. Acta virol.6, 302–308 (1962b).PubMedGoogle Scholar
  18. Wigand, R., u.H. Bauer: Grundlegende Unterschiede in den Eigenschaften der Hämagglutinine verschiedener Adenovirustypen. Zbl. Bakt., I. Abt. Orig.184, 60–65 (1962).Google Scholar
  19. Zhdanov, V. M., andL. B. Mekler: Correlation between the surface structure of viruses and latency. Nature (Lond.)195, 924 (1962).Google Scholar
  20. Zuschek, F.: Studies of the hemagglutinins of type 3, 4 and 7 adenovirus. Proc. Soc. exp. Biol. (N.Y.)107, 27–30 (1961).Google Scholar

Copyright information

© Springer-Verlag 1963

Authors and Affiliations

  • H. Bauer
    • 1
  • R. Wigand
    • 1
  1. 1.Institut für Hygiene und Mikrobiologie der Universität des SaarlandesHomburg (Saar)

Personalised recommendations