Zusammenfassung
Mit vermehrungsfähigen, wie UV-inaktivierten Viren der Pockengruppe konnten in verschiedenen Zellkulturen unter hohen Virus-Zell-Verhältnissen cytotoxische Effekte erzeugt werden. Diese Effekte breiteten sich in den beimpften Kultursystemen nicht stufenweise aus und ließen sich nicht in neuen Kulturen passieren. Die cytotoxische Wirkung war an die Viruspartikeln gebunden. Die veränderten Kulturen zeigten keine erkennbare Virusvermehrung. Der Vergleich dreier Pockenvertreter in bezug auf Cytotoxicität und Virusvermehrung in verschiedenen Kulturen weist darauf hin, daß die Zellen Virus mehr oder weniger stark oder nicht vermehren, während die Bedingungen für eine cytotoxische Wirkung bei allen Vertretern einheitlich sein dürften. Es bestand keine Beziehung zwischen diesen beiden Viruswirkungen. Bezüglich der Virusvermehrung unterscheiden sich die einzelnen Virusarten in verschiedenen Zellsystemen, in ihrer Cytotoxicität reagierten sie jedoch unabhängig vom Zellsystem gleich.
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Mahnel, H. Cytotoxische Wirkung von Pockenviren. Zeitschr. f. Hygiene. 151, 185–198 (1965). https://doi.org/10.1007/BF02157425
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DOI: https://doi.org/10.1007/BF02157425