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In vitro-Untersuchungen mit Poliomyelitisviren unter Dehydro-Cortisol-Einfluß

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Zeitschrift für Hygiene und Infektionskrankheiten, medizinische Mikrobiologie, Immunologie und Virologie Aims and scope Submit manuscript

Zusammenfassung

Mit Hilfe der Immunofluorescenz wurde der Einfluß von Prednisolon auf in vitro Untersuchungen, die mit Poliomyelitisviren Typ I vorgenommen wurden, geprüft. Prednisolon in einer Konzentration von 0,1 und 0,2 mg/ml hat weder einen Einfluß auf die Virusadsorption noch auf dieintracelluläre Virusvermehrung. Prednisolon in einer Konzentration von 1,0 und 2,0 mg/ml verzögert die durch humane Antiseren eingeleitete Neutralisation des Poliomyelitisvirus.

Prednisolon in einer Konzentration von 0,2 mg/ml hemmt deutlich die durch Poliomyelitisviren angeregte Interferonbildung. Der Mechanismus der Prednisolonwirkung wird zur Diskussion gestellt.

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  1. Univ. Kinderklinik München, Deutschland

    O. Goetz & W. Bornschein

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  1. O. Goetz
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  2. W. Bornschein
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Goetz, O., Bornschein, W. In vitro-Untersuchungen mit Poliomyelitisviren unter Dehydro-Cortisol-Einfluß. Zeitschr. f. Hygiene. 151, 160–177 (1965). https://doi.org/10.1007/BF02157422

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  • DOI: https://doi.org/10.1007/BF02157422

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