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The action of tranquilizing drugs on brain metabolism

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Zusammenfassung

Die Tranquilizer Miltown (Meprobamat) und Benactyzin beeinflussen den Gehirnzellstoffwechselin vitro qualitativ wie Largactil, das heisst, sie hemmen die oxydative Phosphorylierung und gleichzeitig auch die ATPase-Aktivität. Demgegenüber hemmt das bloss über eine sedative Wirkung verfügende Captodiamin (Covatin) nur die oxydative Phosphorylierung und lässt die ATPase-Aktivität unbeeinflusst. Dies spricht dafür, dass zur Auslösung einer largactilartigen Wirkung beide oberen Hemmungsprozesse notwendig sind.

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Authors and Affiliations

  1. Institute of Pharmacology, Medical University, Pécs, Hungary

    L. Decsi & J. Méhes

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  1. L. Decsi
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  2. J. Méhes
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Decsi, L., Méhes, J. The action of tranquilizing drugs on brain metabolism. Experientia 14, 145–146 (1958). https://doi.org/10.1007/BF02157128

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