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Der Einfluß von Desoxycorticosteron auf die Azetylcholinwirkung am isolierten Froschherz

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Summary

The action of desoxycorticosteronglucoside was tested on the isolated frog-heart. In concentrations of 10−6 to 10−4 a small negative inotropic effect is prevailing. Acting together with acetylcholine, the substance diminishes or abolishes the negative inotropic and chronotropic action of acetylcholine. Eserin has no influence and the inhibition is also observed with cholinchloride and the carbaminoyl ester of choline. This inhibitory action bears a close resemblance to the inhibitory action of thiamin. In both cases a complex mechanism seems to be involved.

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Literatur

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Authors and Affiliations

  1. Physiologisches Institut der Universität Bern, Switzerland

    F. Gross

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  1. F. Gross
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Gross, F. Der Einfluß von Desoxycorticosteron auf die Azetylcholinwirkung am isolierten Froschherz. Experientia 2, 191–192 (1946). https://doi.org/10.1007/BF02156455

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  • DOI: https://doi.org/10.1007/BF02156455

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