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Recherches sur la pseudo-cholinestérase du sérum et la cholinestérase vraie des globules rouges

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Summary

By means of a technic published in this journal (2, 66 [1946]), it has been observed that the activity of the pseudo-choline esterase of the serum is highest in presence of high concentrations of acetylcholine.

The true choline esterase of the red corpuscules has her optimal activity at concentrations of 200 mg % acetylcholine. This high activity of these choline esterase is only going on during 3 to 5 minutes; after this period an inhibition occurs. At lower substrate concentrations (50 mg % acetylcholine) the difference in activity in the first and second phase is becoming less pronounced and the curve of the choline esterase activity becomes a straight line. At the small substrate concentration (4 mg % acetylcholine) again a primary higher choline esterase activity has been observed.

Choline inhibitsin vitro the activity of the choline esterase. Prostigmine inhibits alsoin vivo andin vitro, the choline esterase of serum and globules.

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Authors and Affiliations

  1. Institut J. F. Heymans de Pharmacodynamie de l'Université de Gand, France

    H. Casier & A. L. Delaunois

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  1. H. Casier
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  2. A. L. Delaunois
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Casier, H., Delaunois, A.L. Recherches sur la pseudo-cholinestérase du sérum et la cholinestérase vraie des globules rouges. Experientia 2, 180–182 (1946). https://doi.org/10.1007/BF02156447

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  • DOI: https://doi.org/10.1007/BF02156447

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